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MedKoo Cat#: 406514 | Name: SB225002
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB225002 is a novel and potent microtubule inhibitor and CXCR2 antagonist with potential anticancer activity. SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro. SB225002 induces apoptosis in both wild-type and p53-deficient ovarian cancer (OVCA) cells through alternative mechanisms. SB225002 promotes mitotic catastrophe, as evidenced by the accumulation of mitotic cells with spindle abnormalities, chromosome mis-segregation, multi-polar cell division, multiple nuclei, aneuploidy/polyploidy and subsequent extensive apoptosis.

Chemical Structure

SB225002
SB225002
CAS#182498-32-4

Theoretical Analysis

MedKoo Cat#: 406514

Name: SB225002

CAS#: 182498-32-4

Chemical Formula: C13H10BrN3O4

Exact Mass: 350.9855

Molecular Weight: 352.14

Elemental Analysis: C, 44.34; H, 2.86; Br, 22.69; N, 11.93; O, 18.17

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
SB225002; SB225002; SB 225002.
IUPAC/Chemical Name
1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea.
InChi Key
MQBZVUNNWUIPMK-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
SMILES Code
O=C(NC1=CC=C([N+]([O-])=O)C=C1O)NC2=CC=CC=C2Br
Appearance
white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
        
Product Data
Product Data
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 352.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bergeron P, Dos Santos M, Sitterle L, Tarlet G, Lavigne J, Liu W, Gerbé de Thoré M, Clémenson C, Meziani L, Schott C, Mazzaschi G, Berthelot K, Benadjaoud MA, Milliat F, Deutsch E, Mondini M. Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade. Nat Commun. 2024 Oct 14;15(1):8845. doi: 10.1038/s41467-024-53015-9. PMID: 39397001; PMCID: PMC11471822. 2: Zhao J, Jian C, Chen Z, Cai J, Zhou C, Li M, Yang Y, Gao Y. Inhibition of CXCR2 as a therapeutic target for chronic post-surgical pain: Insights from animal and cell models. Cytojournal. 2024 Aug 29;21:28. doi: 10.25259/Cytojournal_46_2024. PMID: 39391210; PMCID: PMC11464996. 3: Yang YS, Liu CY, Pei MQ, Sun ZD, Lin S, He HF. Quercetin protects against sepsis-associated encephalopathy by inhibiting microglia-neuron crosstalk via the CXCL2/CXCR2 signaling pathway. Phytomedicine. 2024 Nov;134:155987. doi: 10.1016/j.phymed.2024.155987. Epub 2024 Aug 26. PMID: 39216299. 4: Yu XQ, Mao JZ, Yang SY, Wang L, Yang CZ, Huang L, Qian QH, Zhu TT. Autocrine IL-8 Contributes to Propionibacterium Acnes-induced Proliferation and Differentiation of HaCaT Cells via AKT/FOXO1/ Autophagy. Curr Med Sci. 2024 Aug 28. doi: 10.1007/s11596-024-2894-y. Epub ahead of print. PMID: 39196519. 5: Sun X, Wang C, Cao J, Li J, Ma G, Wu X, Sun P, Wang Y, Huang J, Peter Gale R, Li Z. Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance. J Adv Res. 2024 Aug 19:S2090-1232(24)00366-7. doi: 10.1016/j.jare.2024.08.023. Epub ahead of print. PMID: 39168245. 6: La'ah AS, Tsai PH, Yarmishyn AA, Ching LJ, Chen CY, Chien Y, Chen JC, Tsai ML, Chen YC, Ma C, Hsu PK, Luo YH, Chen YM, Chiou GY, Lu KH, Lin WC, Chou YT, Wang ML, Chiou SH. Neutrophils Recruited by NKX2-1 Suppression via Activation of CXCLs/CXCR2 Axis Promote Lung Adenocarcinoma Progression. Adv Sci (Weinh). 2024 Oct;11(38):e2400370. doi: 10.1002/advs.202400370. Epub 2024 Aug 7. PMID: 39113226; PMCID: PMC11481344. 7: Wu F, Han Y, Xiong Q, Tang H, Shi J, Yang Q, Li X, Jia H, Qian J, Dong Y, Li T, Gao Y, Qian Z, Wang H, Wang T. Cerebral Endothelial CXCR2 Promotes Neutrophil Transmigration into Central Nervous System in LPS-Induced Septic Encephalopathy. Biomedicines. 2024 Jul 11;12(7):1536. doi: 10.3390/biomedicines12071536. PMID: 39062109; PMCID: PMC11274668. 8: Wang Y, Ding W, Hao W, Gong L, Peng Y, Zhang J, Qian Z, Xu K, Cai W, Gao Y. CXCL3/TGF-β-mediated crosstalk between CAFs and tumor cells augments RCC progression and sunitinib resistance. iScience. 2024 Jun 8;27(7):110224. doi: 10.1016/j.isci.2024.110224. PMID: 39040058; PMCID: PMC11261419. 9: Zeng T, Liang L, Deng W, Xie M, Zhao M, Wang S, Liu J, Yang M. BMAL1 plays a crucial role in immune homeostasis during sepsis-induced acute lung injury. Biochem Pharmacol. 2024 Aug;226:116379. doi: 10.1016/j.bcp.2024.116379. Epub 2024 Jun 21. PMID: 38908531. 10: Gu X, Zhu Y, Su J, Wang S, Su X, Ding X, Jiang L, Fei X, Zhang W. Lactate- induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression. Redox Biol. 2024 Aug;74:103209. doi: 10.1016/j.redox.2024.103209. Epub 2024 May 25. PMID: 38861833; PMCID: PMC11215341. 11: Yan D, Wei G, Ai Z, Song S, Zhang L, Dong N, Dou X, Shan A. CXCR2, as a key regulatory gene of HDP-PG-1, maintains intestinal mucosal homeostasis. Int J Biol Macromol. 2024 Jun;269(Pt 2):132025. doi: 10.1016/j.ijbiomac.2024.132025. Epub 2024 May 3. PMID: 38704076. 12: Liao C, Luo S, Liu X, Zhang L, Xie P, Zhou W, Lu Y, Zhong H, Zhang X, Xiong Z, Huang X, Mo G, Ma D, Tang J. Siglec-F+ neutrophils in the spleen induce immunosuppression following acute infection. Theranostics. 2024 Apr 8;14(6):2589-2604. doi: 10.7150/thno.93812. PMID: 38646647; PMCID: PMC11024851. 13: Nie F, Zhang J, Tian H, Zhao J, Gong P, Wang H, Wang S, Yang P, Yang C. The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression. Cell Death Dis. 2024 Apr 18;15(4):277. doi: 10.1038/s41419-024-06640-7. PMID: 38637499; PMCID: PMC11026399. 14: Hou X, Li C, Liu J, Yang S, Peng X, Wang Q, Liu C, Liu X, Luan J, Zhao G, Lin J. Cathelicidin boosts the antifungal activity of neutrophils and improves prognosis during Aspergillus fumigatus keratitis. Infect Immun. 2024 Apr 9;92(4):e0048323. doi: 10.1128/iai.00483-23. Epub 2024 Mar 19. PMID: 38501672; PMCID: PMC11003229. 15: Jiang S, Li W, Song M, Liang J, Liu G, Du Q, Wang L, Meng H, Tang L, Yang Y, Zhang B. CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration. Mol Immunol. 2024 May;169:50-65. doi: 10.1016/j.molimm.2024.03.006. Epub 2024 Mar 16. PMID: 38493581. 16: Ji HZ, Liu B, Ren M, Li S, Zheng JF, Liu TY, Yu HH, Sun Y. The CXCLs-CXCR2 axis modulates the cross-communication between tumor-associated neutrophils and tumor cells in cervical cancer. Expert Rev Clin Immunol. 2024 May;20(5):559-569. doi: 10.1080/1744666X.2024.2305808. Epub 2024 Jan 24. PMID: 38224014. 17: Kim JH, Kang KW, Park Y, Kim BS. CXCR2 inhibition overcomes ponatinib intolerance by eradicating chronic myeloid leukemic stem cells through PI3K/Akt/mTOR and dipeptidylpeptidase Ⅳ (CD26). Heliyon. 2023 Nov 9;9(11):e22091. doi: 10.1016/j.heliyon.2023.e22091. PMID: 38045173; PMCID: PMC10692791. 18: Li DJ, Zhong ZJ, Wang XL, Wei N, Zhao SJ, Shan TT, Liu YP, Yu YQ. Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch. Front Mol Neurosci. 2023 Oct 26;16:1279237. doi: 10.3389/fnmol.2023.1279237. PMID: 37953876; PMCID: PMC10637378. 19: Shu Q, Zhang N, Liu Y, Wang X, Chen J, Xie H, Pan F, Zhao L, Ding X, Wen Y, Wang L, Xie W, Lu J, Su G, Peng H, Yang P. IL-8 Triggers Neutrophil Extracellular Trap Formation Through an Nicotinamide Adenine Dinucleotide Phosphate Oxidase- and Mitogen-Activated Protein Kinase Pathway-Dependent Mechanism in Uveitis. Invest Ophthalmol Vis Sci. 2023 Oct 3;64(13):19. doi: 10.1167/iovs.64.13.19. PMID: 37824136; PMCID: PMC10587853. 20: Ji HZ, Chen L, Ren M, Li S, Liu TY, Chen HJ, Yu HH, Sun Y. CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway. Pharmaceuticals (Basel). 2023 Aug 25;16(9):1210. doi: 10.3390/ph16091210. PMID: 37765018; PMCID: PMC10536478.