MedKoo Cat#: 562767 | Name: Arylquin-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arylquin-1 is a secretagogue of prostate apoptosis response-4 (Par-4). It acts by displacing Par-4 from vimentin for secretion and triggering the efficient paracrine apoptosis of diverse cancer cells.

Chemical Structure

Arylquin-1
CAS#1630743-73-5

Theoretical Analysis

MedKoo Cat#: 562767

Name: Arylquin-1

CAS#: 1630743-73-5

Chemical Formula: C17H16FN3

Exact Mass: 281.1328

Molecular Weight: 281.33

Elemental Analysis: C, 72.58; H, 5.73; F, 6.75; N, 14.94

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 weeks
10mg USD 600.00 2 weeks
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Related CAS #
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Synonym
Arylquin-1; Arylquin 1; Arylquin1;
IUPAC/Chemical Name
3-(2-Fluorophenyl)-N7,N7-dimethylquinoline-2,7-diamine
InChi Key
RHAQINSYYSNKKI-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16FN3/c1-21(2)12-8-7-11-9-14(17(19)20-16(11)10-12)13-5-3-4-6-15(13)18/h3-10H,1-2H3,(H2,19,20)
SMILES Code
NC1=NC2=CC(N(C)C)=CC=C2C=C1C3=CC=CC=C3F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen YT, Tseng TT, Tsai HP, Huang MY. Arylquin 1 (Potent Par-4 Secretagogue) Inhibits Tumor Progression and Induces Apoptosis in Colon Cancer Cells. Int J Mol Sci. 2022 May 18;23(10):5645. doi: 10.3390/ijms23105645. PMID: 35628455; PMCID: PMC9143413. 2: Min KJ, Shahriyar SA, Kwon TK. Arylquin 1, a potent Par-4 secretagogue, induces lysosomal membrane permeabilization-mediated non-apoptotic cell death in cancer cells. Toxicol Res. 2019 Nov 21;36(2):167-173. doi: 10.1007/s43188-019-00025-1. PMID: 32257929; PMCID: PMC7099120. 3: Burikhanov R, Sviripa VM, Hebbar N, Zhang W, Layton WJ, Hamza A, Zhan CG, Watt DS, Liu C, Rangnekar VM. Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis. Nat Chem Biol. 2014 Nov;10(11):924-926. doi: 10.1038/nchembio.1631. Epub 2014 Sep 14. PMID: 25218743; PMCID: PMC4201913.