IUPAC/Chemical Name
(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one
InChi Key
VHCQVGQULWFQTM-VOTSOKGWSA-N
InChi Code
InChI=1S/C20H22O7/c1-23-13-9-15(22)20(19(10-13)27-5)14(21)7-6-12-8-17(25-3)18(26-4)11-16(12)24-2/h6-11,22H,1-5H3/b7-6+
SMILES Code
O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC(OC)=C(OC)C=C2OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
374.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lin F, Wen D, Wang X, Mahato RI. Dual responsive micelles capable of modulating miRNA-34a to combat taxane resistance in prostate cancer. Biomaterials. 2019 Feb;192:95-108. doi: 10.1016/j.biomaterials.2018.10.036. Epub 2018 Nov 3. PMID: 30447399.
2: Wen D, Peng Y, Lin F, Singh RK, Mahato RI. Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer. Cancer Res. 2017 Jun 15;77(12):3244-3254. doi: 10.1158/0008-5472.CAN-16-2355. Epub 2017 Apr 20. PMID: 28428276; PMCID: PMC5673080.
3: Zhang M, Dai T, Feng N. A Novel Solubility-Enhanced Rubusoside-Based Micelles for Increased Cancer Therapy. Nanoscale Res Lett. 2017 Dec;12(1):274. doi: 10.1186/s11671-017-2054-4. Epub 2017 Apr 13. PMID: 28410552; PMCID: PMC5391341.
4: Deng X, Yin Z, Zhou Z, Wang Y, Zhang F, Hu Q, Yang Y, Lu J, Wu Y, Sheng W, Zeng Y. Carboxymethyl Dextran-Stabilized Polyethylenimine-Poly(epsilon- caprolactone) Nanoparticles-Mediated Modulation of MicroRNA-34a Expression via Small-Molecule Modulator for Hepatocellular Carcinoma Therapy. ACS Appl Mater Interfaces. 2016 Jul 13;8(27):17068-79. doi: 10.1021/acsami.6b03122. Epub 2016 Jun 27. PMID: 27300477.
5: Xiao Z, Chen Y. Small molecule targeting miR-34a for cancer therapy. Mol Cell Oncol. 2015 Feb 24;2(1):e977160. doi: 10.4161/23723556.2014.977160. PMID: 27308410; PMCID: PMC4905251.
6: Xiao Z, Li CH, Chan SL, Xu F, Feng L, Wang Y, Jiang JD, Sung JJ, Cheng CH, Chen Y. A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma. Cancer Res. 2014 Nov 1;74(21):6236-47. doi: 10.1158/0008-5472.CAN-14-0855. Epub 2014 Sep 12. PMID: 25217526.