Kinetin | CAS#525-79-1 | furanyl adenine

MedKoo Cat#: 591115 | Name: Kinetin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kinetin is a synthetic cytokinin, a class of plant hormones that promotes cell division and differentiation. Chemically known as N6-furfuryladenine, it is structurally similar to adenine and functions by mimicking natural cytokinins to regulate plant growth and development. It is commonly used in plant tissue culture to stimulate shoot proliferation and delay senescence.

Chemical Structure

Kinetin

CAS#525-79-1

Theoretical Analysis

MedKoo Cat#: 591115

Name: Kinetin

CAS#: 525-79-1

Chemical Formula: C10H9N5O

Exact Mass: 215.0807

Molecular Weight: 215.22

Elemental Analysis: C, 55.81; H, 4.22; N, 32.54; O, 7.43

Price and Availability

Size	Price	Availability	Quantity
5g	USD 350.00	2 Weeks
25g	USD 650.00	2 Weeks

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Related CAS #

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Synonym

Kinetin; NSC 23119; NSC-23119; NSC23119

IUPAC/Chemical Name

9H-Purin-6-amine, N-(2-furanylmethyl)-

InChi Key

QANMHLXAZMSUEX-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H9N5O/c1-2-7(16-3-1)4-11-9-8-10(13-5-12-8)15-6-14-9/h1-3,5-6H,4H2,(H2,11,12,13,14,15)

SMILES Code

9H-Purin-6-amine, N-(2-furanylmethyl)-

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes.

In vitro activity:

The results show a stimulatory effect of kinetin and N6-benzyladenine on antioxidative enzyme activity, as well as reduced glutathione and thiol group content. Cytokinins caused a decrease in membrane phospholipid peroxidation and exhibited protective properties against malondialdehyde production. The present findings reveal that both N6-benzyladenine and kinetin exhibit multiple and complex actions in fibroblast cells in vitro. Reference: Mol Cell Biochem. 2016 Feb;413(1-2):97-107. https://pubmed.ncbi.nlm.nih.gov/26738489/

In vivo activity:

When kinetin was administered at 13 and 14 mg/kg in mice pretreated with fluorescein sodium (5 mg/kg), the occlusion time was significantly prolonged. In conclusion, these results suggest that kinetin has effective free radical-scavenging activity in vitro and antithrombotic activity in vivo. Treatment with kinetin may lower the risk of thromboembolic-related disorders. Reference: Eur J Pharmacol. 2003 Apr 4;465(3):281-7. https://pubmed.ncbi.nlm.nih.gov/12681440/

	Solvent	mg/mL	mM
Solubility
	Water	1.0	4.65

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 215.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Jabłońska-Trypuć A, Matejczyk M, Czerpak R. N6-benzyladenine and kinetin influence antioxidative stress parameters in human skin fibroblasts. Mol Cell Biochem. 2016 Feb;413(1-2):97-107. doi: 10.1007/s11010-015-2642-5. Epub 2016 Jan 6. PMID: 26738489; PMCID: PMC4744253. 2. Hims MM, Ibrahim EC, Leyne M, Mull J, Liu L, Lazaro C, Shetty RS, Gill S, Gusella JF, Reed R, Slaugenhaupt SA. Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl). 2007 Feb;85(2):149-61. doi: 10.1007/s00109-006-0137-2. Epub 2007 Jan 6. PMID: 17206408. 3. Fathy M, Darwish MA, Abdelhamid AM, Alrashedy GM, Othman OA, Naseem M, Dandekar T, Othman EM. Kinetin Ameliorates Cisplatin-Induced Hepatotoxicity and Lymphotoxicity via Attenuating Oxidative Damage, Cell Apoptosis and Inflammation in Rats. Biomedicines. 2022 Jul 6;10(7):1620. doi: 10.3390/biomedicines10071620. PMID: 35884925; PMCID: PMC9312964. 4. Hsiao G, Shen MY, Lin KH, Chou CY, Tzu NH, Lin CH, Chou DS, Chen TF, Sheu JR. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharmacol. 2003 Apr 4;465(3):281-7. doi: 10.1016/s0014-2999(03)01528-0. PMID: 12681440.

In vitro protocol:

In vivo protocol:

1. Fathy M, Darwish MA, Abdelhamid AM, Alrashedy GM, Othman OA, Naseem M, Dandekar T, Othman EM. Kinetin Ameliorates Cisplatin-Induced Hepatotoxicity and Lymphotoxicity via Attenuating Oxidative Damage, Cell Apoptosis and Inflammation in Rats. Biomedicines. 2022 Jul 6;10(7):1620. doi: 10.3390/biomedicines10071620. PMID: 35884925; PMCID: PMC9312964. 2. Hsiao G, Shen MY, Lin KH, Chou CY, Tzu NH, Lin CH, Chou DS, Chen TF, Sheu JR. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharmacol. 2003 Apr 4;465(3):281-7. doi: 10.1016/s0014-2999(03)01528-0. PMID: 12681440.

1: Kaźmierczak A, Soboska K. Fate of nuclear material during subsequent steps of the kinetin-induced PCD in apical parts of Vicia faba ssp. minor seedling roots. Micron. 2018 Apr 30;110:79-87. doi: 10.1016/j.micron.2018.04.009. [Epub ahead of print] PubMed PMID: 29772476. 2: Wei KH, Xu JP, Li LX, Cai JY, Miao JH, Li MH. In vitro Induction and Generation of Tetraploid Plants of Sophora tonkinensis Gapnep. Pharmacogn Mag. 2018 Apr-Jun;14(54):149-154. doi: 10.4103/pm.pm_170_17. Epub 2018 Apr 10. PubMed PMID: 29720823; PubMed Central PMCID: PMC5909307. 3: Li Q, Wang H, Wang H, Zheng W, Wu D, Wang Z. Effects of kinetin on plant growth and chloroplast ultrastructure of two Pteris species under arsenate stress. Ecotoxicol Environ Saf. 2018 Apr 12;158:37-43. doi: 10.1016/j.ecoenv.2018.04.009. [Epub ahead of print] PubMed PMID: 29656162. 4: Mazri MA, Meziani R, Belkoura I, Mokhless B, Nour S. A combined pathway of organogenesis and somatic embryogenesis for an efficient large-scale propagation in date palm (Phoenix dactylifera L.) cv. Mejhoul. 3 Biotech. 2018 Apr;8(4):215. doi: 10.1007/s13205-018-1235-x. Epub 2018 Apr 9. PubMed PMID: 29651380; PubMed Central PMCID: PMC5891445. 5: Zhang L, Hoshika Y, Carrari E, Burkey KO, Paoletti E. Protecting the photosynthetic performance of snap bean under free air ozone exposure. J Environ Sci (China). 2018 Apr;66:31-40. doi: 10.1016/j.jes.2017.05.009. Epub 2017 May 14. PubMed PMID: 29628099. 6: Hönig M, Plíhalová L, Spíchal L, Grúz J, Kadlecová A, Voller J, Svobodová AR, Vostálová J, Ulrichová J, Doležal K, Strnad M. New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress. Eur J Med Chem. 2018 Apr 25;150:946-957. doi: 10.1016/j.ejmech.2018.03.043. Epub 2018 Mar 21. PubMed PMID: 29604584. 7: Bekircan T, Yaşar A, Yıldırım S, Sökmen M, Sökmen A. Effect of cytokinins on in vitro multiplication, volatiles composition and rosmarinic acid content of Thymus leucotrichus Hal. shoots. 3 Biotech. 2018 Mar;8(3):180. doi: 10.1007/s13205-018-1206-2. Epub 2018 Mar 14. PubMed PMID: 29556434; PubMed Central PMCID: PMC5851944. 8: Faisal M, Ahmad N, Anis M, Alatar AA, Qahtan AA. Auxin-cytokinin synergism in vitro for producing genetically stable plants of Ruta graveolens using shoot tip meristems. Saudi J Biol Sci. 2018 Feb;25(2):273-277. doi: 10.1016/j.sjbs.2017.09.009. Epub 2017 Sep 27. PubMed PMID: 29472777; PubMed Central PMCID: PMC5816005. 9: Zafari S, Sharifi M, Chashmi NA. A comparative study of biotechnological approaches for producing valuable flavonoids in Prosopis farcta. Cytotechnology. 2018 Apr;70(2):603-614. doi: 10.1007/s10616-017-0143-y. Epub 2018 Feb 19. PubMed PMID: 29460196; PubMed Central PMCID: PMC5851955. 10: Akitha Devi MK, Kumar SS, Giridhar P. High yield production of folates from soybean callus cultures in response to elicitors. 3 Biotech. 2018 Feb;8(2):80. doi: 10.1007/s13205-018-1101-x. Epub 2018 Jan 15. PubMed PMID: 29430344; PubMed Central PMCID: PMC5796935. 11: Shen HJ, Chen JT, Chung HH, Chang WC. Plant regeneration via direct somatic embryogenesis from leaf explants of Tolumnia Louise Elmore 'Elsa'. Bot Stud. 2018 Jan 22;59(1):4. doi: 10.1186/s40529-018-0220-3. PubMed PMID: 29357024; PubMed Central PMCID: PMC5778089. 12: Venkatachalam P, Jinu U, Sangeetha P, Geetha N, Sahi SV. High frequency plant regeneration from cotyledonary node explants of Cucumis sativus L. cultivar 'Green Long' via adventitious shoot organogenesis and assessment of genetic fidelity by RAPD-PCR technology. 3 Biotech. 2018 Jan;8(1):60. doi: 10.1007/s13205-018-1083-8. Epub 2018 Jan 11. PubMed PMID: 29354371; PubMed Central PMCID: PMC5762594. 13: Modarres M, Esmaeilzadeh Bahabadi S, Taghavizadeh Yazdi ME. Enhanced production of phenolic acids in cell suspension culture of Salvia leriifolia Benth. using growth regulators and sucrose. Cytotechnology. 2018 Apr;70(2):741-750. doi: 10.1007/s10616-017-0178-0. Epub 2018 Jan 18. PubMed PMID: 29349583; PubMed Central PMCID: PMC5851967. 14: Ganeshkumar Y, Ramarao A, Veeresham C. Picroside I and Picroside II from Tissue Cultures of Picrorhiza kurroa. Pharmacognosy Res. 2017 Dec;9(Suppl 1):S53-S56. doi: 10.4103/pr.pr_89_17. PubMed PMID: 29333043; PubMed Central PMCID: PMC5757327. 15: Vishweshwaraiah YL, Prakash B, Gowda LR. Expression profiling of the Dolichos lablab lectin during germination and development of the seed. Plant Physiol Biochem. 2018 Mar;124:10-19. doi: 10.1016/j.plaphy.2017.12.040. Epub 2018 Jan 4. PubMed PMID: 29324242. 16: Kadlecová A, Jirsa T, Novák O, Kammenga J, Strnad M, Voller J. Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans. Biogerontology. 2018 Apr;19(2):109-120. doi: 10.1007/s10522-017-9742-4. Epub 2017 Dec 18. PubMed PMID: 29255944. 17: Bahmankar M, Mortazavian SMM, Tohidfar M, Sadat Noori SA, Izadi Darbandi A, Corrado G, Rao R. Chemical Compositions, Somatic Embryogenesis, and Somaclonal Variation in Cumin. Biomed Res Int. 2017;2017:7283806. doi: 10.1155/2017/7283806. Epub 2017 Nov 6. PubMed PMID: 29234682; PubMed Central PMCID: PMC5694991. 18: Yasin NA, Khan WU, Ahmad SR, Ali A, Ahmad A, Akram W. Imperative roles of halotolerant plant growth-promoting rhizobacteria and kinetin in improving salt tolerance and growth of black gram (Phaseolus mungo). Environ Sci Pollut Res Int. 2018 Feb;25(5):4491-4505. doi: 10.1007/s11356-017-0761-0. Epub 2017 Nov 28. PubMed PMID: 29185225. 19: Sharma U, Kataria V, Shekhawat NS. In vitro propagation, ex vitro rooting and leaf micromorphology of Bauhinia racemosa Lam.: a leguminous tree with medicinal values. Physiol Mol Biol Plants. 2017 Oct;23(4):969-977. doi: 10.1007/s12298-017-0459-2. Epub 2017 Aug 2. PubMed PMID: 29158643; PubMed Central PMCID: PMC5671441. 20: Singh S, Singh A, Srivastava PK, Prasad SM. Cadmium toxicity and its amelioration by kinetin in tomato seedlings vis-à-vis ascorbate-glutathione cycle. J Photochem Photobiol B. 2018 Jan;178:76-84. doi: 10.1016/j.jphotobiol.2017.10.025. Epub 2017 Oct 28. PubMed PMID: 29125985.