|
Solvent |
mg/mL |
mM |
Solubility |
DMSO |
47.0 |
284.52 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
165.19
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Przybyłek M, Ziółkowska D, Mroczyńska K, Cysewski P. Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids. Eur J Pharm Sci. 2016 Mar 31;85:132-40. doi: 10.1016/j.ejps.2016.02.010. Epub 2016 Feb 17. PubMed PMID: 26898408.
2: Moribe K, Tsuchiya M, Tozuka Y, Yamaguchi K, Oguchi T, Yamamoto K. Grinding-induced equimolar complex formation between thiourea and ethenzamide. Chem Pharm Bull (Tokyo). 2004 May;52(5):524-9. PubMed PMID: 15133201.
3: Darias V, Bravo L, Abdallah SS, Sánchez Mateo CC, Expósito-Orta MA, Lissavetsky J, Manzanares J. Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide. Arch Pharm (Weinheim). 1992 Feb;325(2):83-7. PubMed PMID: 1605721.
4: Aitipamula S, Chow PS, Tan RB. Ethenzamide-gentisic acid-acetic acid (2/1/1). Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 10;66(Pt 5):o1045-6. doi: 10.1107/S1600536810012407. PubMed PMID: 21579106; PubMed Central PMCID: PMC2979229.
5: Fukunaka T, Golman B, Shinohara K. Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling. Int J Pharm. 2006 Mar 27;311(1-2):89-96. Epub 2006 Jan 20. PubMed PMID: 16427749.
6: Uehara H, Otsuka H, Izumi K. Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats. Cancer Lett. 1999 Jan 8;135(1):83-90. PubMed PMID: 10077225.
7: Fujimaki Y, Matsubara T, Sakamoto T, Sasakura D, Miura T, Takekawa M, Hiyama Y. Distribution of ethenzamide and other ingredients on granule surfaces studied by Raman microspectroscopy and mapping. Pharmazie. 2009 May;64(5):316-22. PubMed PMID: 19530442.
8: Ozawa M, Hasegawa K, Yonezawa Y, Sunada H. Preparation of solid dispersion for ethenzamide-carbopol and theophylline-carbopol systems using a twin screw extruder. Chem Pharm Bull (Tokyo). 2002 Jun;50(6):802-7. PubMed PMID: 12045335.
9: Aoki S, Mizutani T, Danjo K. Studies on the number of contacts between ibuprofen and ethenzamide using thermal analysis. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):140-1. PubMed PMID: 10705490.
10: Hirasawa N, Okamoto H, Danjo K. Lactose as a low molecular weight carrier of solid dispersions for carbamazepine and ethenzamide. Chem Pharm Bull (Tokyo). 1999 Mar;47(3):417-20. PubMed PMID: 10212391.
11: Shibasaki J, Konishi R, Takemura M, Fukushima E, Nakamura J, Sasaki H. Comparison of the first-pass metabolism of ethenzamide and salicylamide in rats. J Pharmacobiodyn. 1984 Nov;7(11):804-10. PubMed PMID: 6530645.
12: Fukunaka T, Golman B, Shinohara K. Continuous grinding kinetics of ethenzamide particles by fluidized-bed jet-milling. Drug Dev Ind Pharm. 2006 Mar;32(3):347-55. PubMed PMID: 16556539.
13: Asada S, Fujii H, Nakae H. [Application of multi-lines fitting technic for ethenzamide elimination with capacity-limited process in the rabbit plasma]. Yakugaku Zasshi. 1989 Jul;109(7):499-504. Japanese. PubMed PMID: 2585261.
14: Kawano O, Sawabe T, Misaki N, Fukawa K. Studies on combination dosing (III). Aspirin and ethenzamide. Jpn J Pharmacol. 1978 Dec;28(6):829-35. PubMed PMID: 745307.
15: Kondo K, Kato A, Niwa T. Development of a novel pelletization technique through an extremely high-shear process using a mechanical powder processor to produce high-dose small core granules suitable for film coating. Int J Pharm. 2015 Apr 10;483(1-2):101-9. doi: 10.1016/j.ijpharm.2015.02.026. Epub 2015 Feb 11. PubMed PMID: 25681728.