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MedKoo Cat#: 591114 | Name: Adenine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adenine a purine base and a fundamental unit of ADENINE NUCLEOTIDES.

Chemical Structure

Adenine
CAS#73-24-5 (free base)

Theoretical Analysis

MedKoo Cat#: 591114

Name: Adenine

CAS#: 73-24-5 (free base)

Chemical Formula: C5H5N5

Exact Mass: 135.0545

Molecular Weight: 135.13

Elemental Analysis: C, 44.44; H, 3.73; N, 51.83

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 weeks
25g USD 450.00 2 weeks
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Related CAS #
2922-28-3 (HCl) 73-24-5 (free base)
Synonym
Adenine; NSC 14666; NSC-14666; NSC14666
IUPAC/Chemical Name
1H-Purin-6-amine
InChi Key
GFFGJBXGBJISGV-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
SMILES Code
NC1=C2N=CN=C2N=CN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 135.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhu D, Zhao D, Huang J, Zhu Y, Chao J, Su S, Li J, Wang L, Shi J, Zuo X, Weng L, Li Q, Wang L. Poly-Adenine-Mediated Fluorescent Spherical Nucleic Acid Probes for Live-Cell Imaging of Endogenous Tumor-Related mRNA. Nanomedicine. 2018 May 16. pii: S1549-9634(18)30097-2. doi: 10.1016/j.nano.2018.05.006. [Epub ahead of print] PubMed PMID: 29777876. 2: Ye Z, Zhang X, Zhu Y, Song T, Chen X, Lei X, Wang C. Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 May 15. doi: 10.1021/acs.molpharmaceut.8b00250. [Epub ahead of print] PubMed PMID: 29763317. 3: Mukherjee R, Moreno-Fernandez ME, Giles DA, Cappelletti M, Stankiewicz TE, Chan CC, Divanovic S. Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice. Hepatol Commun. 2018 Mar 24;2(5):546-560. doi: 10.1002/hep4.1162. eCollection 2018 May. PubMed PMID: 29761170; PubMed Central PMCID: PMC5944572. 4: Zhihui-Yao P, Yang-Xu MD, Weidong-Ma MD, Sun XY, Shan-Jia P, Yang-Zheng MD, Xiaohuan-Liu MD, Yajie-Fan MD, Congxia-Wang MD. Magnesium Citrate Protects Against Vascular Calcification in an Adenine-Induced Crf Rat Model. J Cardiovasc Pharmacol. 2018 Apr 24. doi: 10.1097/FJC.0000000000000590. [Epub ahead of print] PubMed PMID: 29738375. 5: Weng XF, Li ST, Song Q, Zhu Q, Song DD, Qin ZH, Xie Y. Protective Effect of Nicotinamide Adenine Dinucleotide Phosphate on Renal Ischemia-Reperfusion Injury. Kidney Blood Press Res. 2018 May 3;43(3):651-663. doi: 10.1159/000489620. [Epub ahead of print] PubMed PMID: 29734167. 6: Otręba M, Budzikur D, Górecki Ł, Řlepokura KA. Adenosine hypodiphosphate ester, an analogue of ADP: analysis of the adenine-hypodiphosphate interaction mode in hypodiphosphate nucleotides and adenine salts. Acta Crystallogr C Struct Chem. 2018 May 1;74(Pt 5):571-583. doi: 10.1107/S2053229618005089. Epub 2018 Apr 11. PubMed PMID: 29726466. 7: Antill LM, Woodward JR. Flavin Adenine Dinucleotide Photochemistry Is Magnetic Field Sensitive at Physiological pH. J Phys Chem Lett. 2018 May 17;9(10):2691-2696. doi: 10.1021/acs.jpclett.8b01088. Epub 2018 May 8. PubMed PMID: 29724094. 8: Ryu SM, Koo T, Kim K, Lim K, Baek G, Kim ST, Kim HS, Kim DE, Lee H, Chung E, Kim JS. Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy. Nat Biotechnol. 2018 Apr 27. doi: 10.1038/nbt.4148. [Epub ahead of print] PubMed PMID: 29702637. 9: Pavithra GC, Ramagopal UA. Crystal structures of APRT from Francisella tularensis: An N-H N hydrogen bond imparts adenine specificity in adenine phosporibosyltransferases. FEBS J. 2018 Apr 25. doi: 10.1111/febs.14481. [Epub ahead of print] PubMed PMID: 29694705. 10: Arabi AA, Matta CF. Adenine-thymine tautomerization under the influence of strong homogeneous electric fields. Phys Chem Chem Phys. 2018 May 9;20(18):12406-12412. doi: 10.1039/c8cp01122b. PubMed PMID: 29693088. 11: Liang Z, Yu G, Liu J, Geng Y, Mao J, Wang D, Zhou J, Gu X. The N(6)-adenine methylation in yeast genome profiled by single-molecule technology. J Genet Genomics. 2018 Mar 28. pii: S1673-8527(18)30058-4. doi: 10.1016/j.jgg.2018.03.003. [Epub ahead of print] PubMed PMID: 29685735. 12: Zhu CZ, Doyle KJ, Nikkel AL, Olsen L, Namovic MT, Salte K, Widomski D, Su Z, Donnelly-Roberts DL, Gopalakrishnan MM, McGaraughty S. Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats. J Pharmacol Toxicol Methods. 2018 Apr 22;94(Pt 1):34-43. doi: 10.1016/j.vascn.2018.04.003. [Epub ahead of print] PubMed PMID: 29684554. 13: Mohaček-Grošev V, Gebavi H, Bonifacio A, Sergo V, Daković M, Bajuk-Bogdanović D. Binding of p-mercaptobenzoic acid and adenine to gold-coated electroless etched silicon nanowires studied by surface-enhanced Raman scattering. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jul 5;200:102-109. doi: 10.1016/j.saa.2018.04.016. Epub 2018 Apr 10. PubMed PMID: 29677496. 14: Yang J, Li Q, M Henning S, Zhong J, Hsu M, Lee R, Long J, Chan B, T Nagami G, Heber D, Li Z. Effects of Prebiotic Fiber Xylooligosaccharide in Adenine induced Nephropathy in Mice. Mol Nutr Food Res. 2018 Apr 20:e1800014. doi: 10.1002/mnfr.201800014. [Epub ahead of print] PubMed PMID: 29676858. 15: Luo M, Groaz E, De Jonghe S, Snoeck R, Andrei G, Herdewijn P. Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity. ACS Med Chem Lett. 2018 Mar 16;9(4):381-385. doi: 10.1021/acsmedchemlett.8b00079. eCollection 2018 Apr 12. PubMed PMID: 29670705; PubMed Central PMCID: PMC5900341. 16: Lozoya OA, Martinez-Reyes I, Wang T, Grenet D, Bushel P, Li J, Chandel N, Woychik RP, Santos JH. Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation. PLoS Biol. 2018 Apr 18;16(4):e2005707. doi: 10.1371/journal.pbio.2005707. eCollection 2018 Apr. PubMed PMID: 29668680; PubMed Central PMCID: PMC5927466. 17: Prieto SG, Silva JCS, de Lima MO, Almeida MC, Echeverry MB. Cross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatum. Behav Pharmacol. 2018 Apr 16. doi: 10.1097/FBP.0000000000000406. [Epub ahead of print] PubMed PMID: 29664745. 18: Zhu SY, Zhuang JS, Wu Q, Liu ZY, Liao CR, Luo SG, Chen JT, Zhong ZM. Advanced oxidation protein products induce pre-osteoblast apoptosis through a nicotinamide adenine dinucleotide phosphate oxidase-dependent, mitogen-activated protein kinases-mediated intrinsic apoptosis pathway. Aging Cell. 2018 Apr 16:e12764. doi: 10.1111/acel.12764. [Epub ahead of print] PubMed PMID: 29659123. 19: Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H. DNA N(6)-Adenine Methylation in Arabidopsis thaliana. Dev Cell. 2018 May 7;45(3):406-416.e3. doi: 10.1016/j.devcel.2018.03.012. Epub 2018 Apr 12. PubMed PMID: 29656930. 20: Rivera-Valdés JJ, García-Bañuelos J, Salazar-Montes A, García-Benavides L, Dominguez-Rosales A, Armendáriz-Borunda J, Sandoval-Rodríguez A. Correction: Human adipose derived stem cells regress fibrosis in a chronic renal fibrotic model induced by adenine. PLoS One. 2018 Apr 13;13(4):e0196045. doi: 10.1371/journal.pone.0196045. eCollection 2018. PubMed PMID: 29652943; PubMed Central PMCID: PMC5898742.

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