GCA-186 | CAS#149950-61-8 | HIV-1 transcriptase inhibitor

MedKoo Cat#: 562759 | Name: GCA-186

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GCA-186 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.

Chemical Structure

GCA-186

CAS#149950-61-8

Theoretical Analysis

MedKoo Cat#: 562759

Name: GCA-186

CAS#: 149950-61-8

Chemical Formula: C19H26N2O3

Exact Mass: 330.1943

Molecular Weight: 330.42

Elemental Analysis: C, 69.06; H, 7.93; N, 8.48; O, 14.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GCA-186; GCA 186; GCA186; I-EBU-dM; I EBU dM; IEBUdM;

IUPAC/Chemical Name

6-[(3,5-Dimethylphenyl)methyl]-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione

InChi Key

NVGVZWUORYLPAL-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H26N2O3/c1-6-24-11-21-16(10-15-8-13(4)7-14(5)9-15)17(12(2)3)18(22)20-19(21)23/h7-9,12H,6,10-11H2,1-5H3,(H,20,22,23)

SMILES Code

O=C1NC(C(C(C)C)=C(CC2=CC(C)=CC(C)=C2)N1COCC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 330.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: El-Brollosy NR, Sørensen ER, Pedersen EB, Sanna G, La Colla P, Loddo R. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008 Jan;341(1):9-19. PubMed PMID: 18161905. 2: Sørensen ER, El-Brollosy NR, Jørgensen PT, Pedersen EB, Nielsen C. Synthesis of 6-(3,5-dichlorobenzyl) derivatives as isosteric analogues of the HIV drug 6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-isopropyluracil (GCA-186). Arch Pharm (Weinheim). 2005 Jul;338(7):299-304. PubMed PMID: 15996003. 3: Hopkins AL, Ren J, Tanaka H, Baba M, Okamato M, Stuart DI, Stammers DK. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999 Nov 4;42(22):4500-5. PubMed PMID: 10579814.