MedKoo Cat#: 591091 | Name: Cephalexin hydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefalexin, also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections. It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. Cefalexin is a β-lactam antibiotic of the cephalosporin family. It is bactericidal and acts by inhibiting synthesis of the peptidoglycan layer of the bacterial cell wall. As cefalexin closely resembles d-alanyl-d-alanine, an amino acid ending on the peptidoglycan layer of the cell wall, it is able to irreversibly bind to the active site of PBP, which is essential for the synthesis of the cell wall. It is most active against gram-positive cocci, and has moderate activity against some gram-negative bacilli.

Chemical Structure

Cephalexin hydrate
CAS#23325-78-2 (hydrate)

Theoretical Analysis

MedKoo Cat#: 591091

Name: Cephalexin hydrate

CAS#: 23325-78-2 (hydrate)

Chemical Formula: C16H19N3O5S

Exact Mass: 0.0000

Molecular Weight: 365.40

Elemental Analysis: C, 52.59; H, 5.24; N, 11.50; O, 21.89; S, 8.77

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
10g USD 450.00 2 Weeks
25g USD 750.00 2 Weeks
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Synonym
Cephalexin hydrate; Cefalival; Cefibacter; Cephalexin Monohydrate
IUPAC/Chemical Name
(6R,7R)-7-((R)-2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
InChi Key
AVGYWQBCYZHHPN-CYJZLJNKSA-N
InChi Code
InChI=1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15-;/m1./s1
SMILES Code
O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O.[H]O[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 365.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kanan M, Atif S, Mohammed F, Balahmar Y, Adawi Y, AlSaleem R, Farhan A, Alghoribi M, Mohammed S, Alshanbari R, Fahad M, Kallab R, Mohammed R, Alassaf D, Hazza A. A Systematic Review on the Clinical Pharmacokinetics of Cephalexin in Healthy and Diseased Populations. Antibiotics (Basel). 2023 Sep 3;12(9):1402. doi: 10.3390/antibiotics12091402. PMID: 37760698; PMCID: PMC10526061. 2: Gan A, Delgado L, Swafford K, Brown D, Soneji M. Hemorrhagic Cystitis Due to Cephalexin and Review of the Literature. Clin Pediatr (Phila). 2024 Mar;63(3):423-427. doi: 10.1177/00099228231175473. Epub 2023 May 19. PMID: 37208912; PMCID: PMC10893768. 3: Yu D, Bio LL. Shedding Light on Amoxicillin, Amoxicillin-clavulanate, and Cephalexin Dosing in Children from a Pharmacist's Perspective. J Pediatric Infect Dis Soc. 2022 Dec 28;11(12):594-602. doi: 10.1093/jpids/piac105. PMID: 36112500. 4: Cárdenas Sierra RS, Zúñiga-Benítez H, Peñuela GA. Elimination of cephalexin and doxycycline under low frequency ultrasound. Ultrason Sonochem. 2021 Nov;79:105777. doi: 10.1016/j.ultsonch.2021.105777. Epub 2021 Oct 7. PMID: 34649167; PMCID: PMC8517921. 5: Ali Noman E, Al-Gheethi A, Saphira Radin Mohamed RM, Talip BA, Hossain MS, Ali Hamood Altowayti W, Ismail N. Sustainable approaches for removal of cephalexin antibiotic from non-clinical environments: A critical review. J Hazard Mater. 2021 Sep 5;417:126040. doi: 10.1016/j.jhazmat.2021.126040. Epub 2021 May 8. PMID: 34000703. 6: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Cephalexin. 2021 Jan 18. PMID: 30000547. 7: Nguyen HM, Graber CJ. A Critical Review of Cephalexin and Cefadroxil for the Treatment of Acute Uncomplicated Lower Urinary Tract Infection in the Era of "Bad Bugs, Few Drugs". Int J Antimicrob Agents. 2020 Oct;56(4):106085. doi: 10.1016/j.ijantimicag.2020.106085. Epub 2020 Jul 10. PMID: 32659466. 8: Spelber D, Lahijani S. Neurosyphilis Presenting as Mania and Psychosis After Incidental Treatment With Cephalexin: A Case Report and Literature Review of Jarisch-Herxheimer Reactions. Psychosomatics. 2020 Mar-Apr;61(2):177-180. doi: 10.1016/j.psym.2019.06.001. Epub 2019 Jun 19. PMID: 31331661. 9: Miller LG. Cephalexin plus trimethoprim-sulfamethoxazole was not superior to cephalexin alone for the treatment of outpatient non-purulent cellulitis. Evid Based Med. 2017 Dec;22(6):213. doi: 10.1136/ebmed-2017-110796. Epub 2017 Nov 10. PMID: 29127212. 10: Patel R, Amber KT. Thrombotic thrombocytopenic purpura in a postoperative patient taking cephalexin responding to plasmapheresis: A case report and review of cephalosporin-induced TTP. J Clin Apher. 2016 Oct;31(5):473-5. doi: 10.1002/jca.21420. Epub 2015 Aug 14. PMID: 26274019. 11: McCloskey GL, Massa MC. Cephalexin rash in infectious mononucleosis. Cutis. 1997 May;59(5):251-4. PMID: 9169264. 12: Murray KM, Camp MS. Cephalexin-induced Stevens-Johnson syndrome. Ann Pharmacother. 1992 Oct;26(10):1230-3. doi: 10.1177/106002809202601006. PMID: 1421644. 13: Tanrisever B, Santella PJ. Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine. Drugs. 1986;32 Suppl 3:1-16. doi: 10.2165/00003495-198600323-00003. PMID: 3542485. 14: Polastri F, Ruffino S, Benech A, Tarello F, Manzon W, Giordano M. Valutazioni sull'impiego della cefalexina monoidrato nella profilassi postoperatoria in chirurgia orale [Evaluation of the use of cephalexin monohydrate in postoperative prophylaxis in oral surgery]. Minerva Stomatol. 1983 Jul-Aug;32(4):617-21. Italian. PMID: 6358852. 15: Jones RN, Preston DA. The antimicrobial activity of cephalexin against old and new pathogens. Postgrad Med J. 1983;59 Suppl 5:9-15. PMID: 6364091. 16: Derrick CW Jr, Reilly K. The role of cephalexin in the treatment of skin and soft-tissue infections. Postgrad Med J. 1983;59 Suppl 5:43-6. PMID: 6364089. 17: Raff MJ. Cephalexin in lower respiratory tract infections. Postgrad Med J. 1983;59 Suppl 5:32-9. PMID: 6364088. 18: Disney FA. Cephalexin in the treatment of upper respiratory tract infections. Postgrad Med J. 1983;59 Suppl 5:28-31. PMID: 6364087. 19: Griffith RS. The pharmacology of cephalexin. Postgrad Med J. 1983;59 Suppl 5:16-27. PMID: 6364086. 20: Speight TM, Brogden RN, Avery GS. Cephalexin: a review of its antibacterial, pharmacological and therapeutic properties. Drugs. 1972;3(1):9-78. doi: 10.2165/00003495-197203010-00002. PMID: 4559812.