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MedKoo Cat#: 562747 | Name: Curculigoside A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Curculigoside A is an inducer of angiogenesis through VCAM-1/Egr-3/CREB/VEGF signaling pathway.

Chemical Structure

Curculigoside A
Curculigoside A
CAS#85643-19-2

Theoretical Analysis

MedKoo Cat#: 562747

Name: Curculigoside A

CAS#: 85643-19-2

Chemical Formula: C22H26O11

Exact Mass: 466.1475

Molecular Weight: 466.43

Elemental Analysis: C, 56.65; H, 5.62; O, 37.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
143601-09-6 (Curculigoside B)
Synonym
Curculigoside A; Curculigoside-A;
IUPAC/Chemical Name
[5-Hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl 2,6-dimethoxybenzoate
InChi Key
SJJRKHVKAXVFJQ-QKYBYQKWSA-N
InChi Code
InChI=1S/C22H26O11/c1-29-14-4-3-5-15(30-2)17(14)21(28)31-10-11-8-12(24)6-7-13(11)32-22-20(27)19(26)18(25)16(9-23)33-22/h3-8,16,18-20,22-27H,9-10H2,1-2H3/t16-,18-,19+,20-,22-/m1/s1
SMILES Code
O=C(OCC1=CC(O)=CC=C1O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C3=C(OC)C=CC=C3OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 466.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang Y, Ying S, Li T, Zhen J, Chen D, Wang J. A sensitive LC-MS/MS-based bioanalytical method for quantification of salviaflaside and rosmarinic acid in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2018 Apr 14:e4259. doi: 10.1002/bmc.4259. [Epub ahead of print] PubMed PMID: 29655233. 2: Miao M, Tian S, Guo L, Bai M, Fang X, Liu S. The effect of curculigoside on mouse model of perimenopausal depression. Saudi J Biol Sci. 2017 Dec;24(8):1894-1902. doi: 10.1016/j.sjbs.2017.11.033. Epub 2017 Nov 11. PubMed PMID: 29551941; PubMed Central PMCID: PMC5851930. 3: Wang N, Zhang Q, Xin H, Shou D, Qin L. Osteoblast cell membrane chromatography coupled with liquid chromatography and time-of-flight mass spectrometry for screening specific active components from traditional Chinese medicines. J Sep Sci. 2017 Nov;40(22):4311-4319. doi: 10.1002/jssc.201700688. Epub 2017 Oct 6. PubMed PMID: 28884956. 4: Wang L, He YJ, Han T, Zhao L, Lv L, He YQ, Zhang QY, Xin HL. Metabolites of curculigoside in rats and their antiosteoporotic activities in osteoblastic MC3T3-E1 cells. Fitoterapia. 2017 Mar;117:109-117. doi: 10.1016/j.fitote.2017.01.009. Epub 2017 Jan 24. PubMed PMID: 28126417. 5: Lang J, Li W, Zhao J, Wang K, Chen D. Inhibitory effects of curculigoside on human liver cytochrome P450 enzymes. Xenobiotica. 2017 Oct;47(10):849-855. doi: 10.1080/00498254.2016.1257171. Epub 2017 Jul 3. PubMed PMID: 27819189. 6: Chaturvedi P, Briganza V. Enhanced Synthesis of Curculigoside by Stress and Amino Acids in Static Culture of Curculigo orchioides Gaertn (Kali Musli). Pharmacognosy Res. 2016 Jul-Sep;8(3):193-8. doi: 10.4103/0974-8490.182915. PubMed PMID: 27365988; PubMed Central PMCID: PMC4908848. 7: Wang K, Zhao J, Lang J. The effects of verapamil on the pharmacokinetics of curculigoside in rats. Pharm Biol. 2016 Dec;54(12):3001-3008. Epub 2016 Jun 22. PubMed PMID: 27328778. 8: Ooi DJ, Chan KW, Sarega N, Alitheen NB, Ithnin H, Ismail M. Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent. Molecules. 2016 Jun 17;21(6). pii: E682. doi: 10.3390/molecules21060682. PubMed PMID: 27322226. 9: Murali VP, Kuttan G. Curculigoside augments cell-mediated immune responses in metastatic tumor-bearing animals. Immunopharmacol Immunotoxicol. 2016 Aug;38(4):264-9. doi: 10.1080/08923973.2016.1188401. Epub 2016 May 26. PubMed PMID: 27228189. 10: Ding H, Gao G, Zhang L, Shen G, Sun W, Gu Z, Fan W. The protective effects of curculigoside A on adjuvant-induced arthritis by inhibiting NF-кB/NLRP3 activation in rats. Int Immunopharmacol. 2016 Jan;30:43-49. doi: 10.1016/j.intimp.2015.11.026. Epub 2015 Nov 27. PubMed PMID: 26637957. 11: Zhu FB, Wang JY, Zhang YL, Quan RF, Yue ZS, Zeng LR, Zheng WJ, Hou Q, Yan SG, Hu YG. Curculigoside regulates proliferation, differentiation, and pro-inflammatory cytokines levels in dexamethasone-induced rat calvarial osteoblasts. Int J Clin Exp Med. 2015 Aug 15;8(8):12337-46. eCollection 2015. PubMed PMID: 26550143; PubMed Central PMCID: PMC4612828. 12: Zhu H, He J, Ye L, Lin F, Hou J, Zhong Y, Jiang W. Mechanisms of angiogenesis in a Curculigoside A-treated rat model of cerebral ischemia and reperfusion injury. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):313-21. doi: 10.1016/j.taap.2015.08.003. Epub 2015 Aug 14. PubMed PMID: 26283324. 13: Zhao L, Liu S, Wang Y, Zhang Q, Zhao W, Wang Z, Yin M. Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP/PS1 Mutated Transgenic Mice. PLoS One. 2015 Jul 17;10(7):e0133289. doi: 10.1371/journal.pone.0133289. eCollection 2015. PubMed PMID: 26186010; PubMed Central PMCID: PMC4505858. 14: Tundis R, Loizzo MR, Bonesi M, Menichini F. Potential role of natural compounds against skin aging. Curr Med Chem. 2015;22(12):1515-38. Review. PubMed PMID: 25723509. 15: Tacchini M, Spagnoletti A, Marieschi M, Caligiani A, Bruni R, Efferth T, Sacchetti G, Guerrini A. Phytochemical profile and bioactivity of traditional ayurvedic decoctions and hydro-alcoholic macerations of Boerhaavia diffusa L. and Curculigo orchioides Gaertn. Nat Prod Res. 2015;29(22):2071-9. doi: 10.1080/14786419.2014.1003299. Epub 2015 Jan 22. PubMed PMID: 25612143. 16: Yuan TT, Xu HT, Zhao L, Lv L, He YJ, Zhang ND, Qin LP, Han T, Zhang QY. Pharmacokinetic and tissue distribution profile of curculigoside after oral and intravenously injection administration in rats by liquid chromatography-mass spectrometry. Fitoterapia. 2015 Mar;101:64-72. doi: 10.1016/j.fitote.2014.12.012. Epub 2014 Dec 27. PubMed PMID: 25549926. 17: He Y, Dong X, Jia X, Li M, Yuan T, Xu H, Qin L, Han T, Zhang Q. Qualitative and quantitative analysis on chemical constituents from Curculigo orchioides using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J Pharm Biomed Anal. 2015 Jan;102:236-45. doi: 10.1016/j.jpba.2014.09.024. Epub 2014 Sep 28. PubMed PMID: 25305598. 18: Kang Z, Zhu H, Luan H, Han F, Jiang W. Curculigoside A induces angiogenesis through VCAM-1/Egr-3/CREB/VEGF signaling pathway. Neuroscience. 2014 May 16;267:232-40. doi: 10.1016/j.neuroscience.2014.02.050. Epub 2014 Mar 12. Erratum in: Neuroscience. 2014 Sep 5;275:1. PubMed PMID: 24631678. 19: Liu M, Li Y, Yang ST. Curculigoside improves osteogenesis of human amniotic fluid-derived stem cells. Stem Cells Dev. 2014 Jan 15;23(2):146-54. doi: 10.1089/scd.2013.0261. Epub 2013 Oct 5. PubMed PMID: 24007307. 20: Zhao G, Yuan F, Zhu J. An LC-MS/MS method for determination of curculigoside with anti-osteoporotic activity in rat plasma and application to a pharmacokinetic study. Biomed Chromatogr. 2014 Mar;28(3):341-7. doi: 10.1002/bmc.3025. Epub 2013 Sep 2. PubMed PMID: 23996522.