MedKoo Cat#: 112099 | Name: 4-Hydroxyphenylacetic Acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory activity and inhibits seawater instillation-induced increases in TNF-α, IL-1β, and IL-6 levels in lung tissue and white blood cell numbers in bronchoalveolar lavage fluid (BALF). Serum levels of 4-hydroxyphenylacetic acid are increased in patients with stage III pancreatic cancer.

Chemical Structure

4-Hydroxyphenylacetic Acid
4-Hydroxyphenylacetic Acid
CAS#156-38-7

Theoretical Analysis

MedKoo Cat#: 112099

Name: 4-Hydroxyphenylacetic Acid

CAS#: 156-38-7

Chemical Formula: C8H8O3

Exact Mass: 152.0473

Molecular Weight: 152.15

Elemental Analysis: C, 63.15; H, 5.30; O, 31.55

Price and Availability

Size Price Availability Quantity
25g USD 250.00 2 Weeks
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Related CAS #
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Synonym
4-Hydroxyphenylacetic Acid; 4Hydroxyphenylacetic Acid; 4 Hydroxyphenylacetic Acid; 4-HPAA; p-HPAA; para-HPAA; p-Hydroxyphenylacetic Acid; para-Hydroxyphenylacetic Acid; NSC 25066; NSC 27460
IUPAC/Chemical Name
2-(4-hydroxyphenyl)acetic acid
InChi Key
XQXPVVBIMDBYFF-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
SMILES Code
OC1=CC=C(C=C1)CC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 1.0 6.57
PBS (pH:7.2) 10.0 65.72
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 152.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao H, Jiang Z, Chang X, Xue H, Yahefu W, Zhang X. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. doi: 10.3389/fphar.2018.00653. PMID: 29973881; PMCID: PMC6020787. 2: Liu Z, Xi R, Zhang Z, Li W, Liu Y, Jin F, Wang X. 4-hydroxyphenylacetic acid attenuated inflammation and edema via suppressing HIF-1α in seawater aspiration- induced lung injury in rats. Int J Mol Sci. 2014 Jul 21;15(7):12861-84. doi: 10.3390/ijms150712861. PMID: 25050781; PMCID: PMC4139878. 3: Shen YP, Pan Y, Niu FX, Liao YL, Huang M, Liu JZ. Biosensor-assisted evolution for high-level production of 4-hydroxyphenylacetic acid in Escherichia coli. Metab Eng. 2022 Mar;70:1-11. doi: 10.1016/j.ymben.2021.12.008. Epub 2021 Dec 26. PMID: 34965469.