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MedKoo Cat#: 596054 | Name: Telmisartan methyl ester

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Telmisartan methyl ester is an impurity found in Telmisartan.

Chemical Structure

Telmisartan methyl ester
Telmisartan methyl ester
CAS#528560-93-2 (methyl ester)

Theoretical Analysis

MedKoo Cat#: 596054

Name: Telmisartan methyl ester

CAS#: 528560-93-2 (methyl ester)

Chemical Formula: C34H32N4O2

Exact Mass: 528.2525

Molecular Weight: 528.65

Elemental Analysis: C, 77.25; H, 6.10; N, 10.60; O, 6.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
144701-48-4 528560-93-2 (methyl ester)
Synonym
Telmisartan methyl ester; J3.264.806A;
IUPAC/Chemical Name
methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
InChi Key
HJCCZIABCSDUPE-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H32N4O2/c1-5-10-31-36-32-22(2)19-25(33-35-28-13-8-9-14-29(28)37(33)3)20-30(32)38(31)21-23-15-17-24(18-16-23)26-11-6-7-12-27(26)34(39)40-4/h6-9,11-20H,5,10,21H2,1-4H3
SMILES Code
O=C(C1=CC=CC=C1C2=CC=C(CN3C4=CC(C5=NC6=CC=CC=C6N5C)=CC(C)=C4N=C3CCC)C=C2)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 528.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sadek SA, Rashed LA, Bassam AM, Said ES. Effect of aliskiren, telmisartan and torsemide on cardiac dysfunction in l-nitro arginine methyl ester (l-NAME) induced hypertension in rats. J Adv Res. 2015 Nov;6(6):967-74. doi: 10.1016/j.jare.2014.11.003. Epub 2014 Nov 20. PubMed PMID: 26644935; PubMed Central PMCID: PMC4642170. 2: Kocak C, Kocak FE, Akcilar R, Bayat Z, Aras B, Metineren MH, Yucel M, Simsek H. Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study. Clin Exp Pharmacol Physiol. 2016 Feb;43(2):230-41. doi: 10.1111/1440-1681.12511. PubMed PMID: 26515498. 3: Nirwane A, Pawar V, Majumdar A. Therapeutic interventions using a combination of Telmisartan and omega 3-fatty acids in sodium arsenite-induced vascular endothelial dysfunction in rats: modulation through ATP-sensitive K+ channels and eNOS. J Complement Integr Med. 2015 Jun;12(2):143-51. doi: 10.1515/jcim-2015-0009. PubMed PMID: 25870973. 4: Chopra A. (11)C-Labeled Telmisartan, an angiotensin II type 1 receptor antagonist. 2012 Jul 30 [updated 2012 Aug 30]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK100266/ PubMed PMID: 22953357. 5: Kagota S, Tada Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K. Telmisartan provides protection against development of impaired vasodilation independently of metabolic effects in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome. Can J Physiol Pharmacol. 2011 May;89(5):355-64. doi: 10.1139/y11-029. Epub 2011 May 27. PubMed PMID: 21619437. 6: Yuen CY, Wong WT, Tian XY, Wong SL, Lau CW, Yu J, Tomlinson B, Yao X, Huang Y. Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovasc Res. 2011 Apr 1;90(1):122-9. doi: 10.1093/cvr/cvq392. Epub 2010 Dec 14. PubMed PMID: 21156825. 7: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Sep;30(7):543-88. PubMed PMID: 18985183. 8: Takahashi T, Ono H, Ono Y, Ishimitsu T, Matsuoka H. Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). Int Heart J. 2007 Sep;48(5):637-47. PubMed PMID: 17998773. 9: Vongpatanasin W, Thomas GD, Schwartz R, Cassis LA, Osborne-Lawrence S, Hahner L, Gibson LL, Black S, Samols D, Shaul PW. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation. 2007 Feb 27;115(8):1020-8. Epub 2007 Feb 5. PubMed PMID: 17283257. 10: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Oct;28(8):533-91. PubMed PMID: 17136234. 11: Pieber D, Horina G, Sandner-Kiesling A, Pieber TR, Heinemann A. Pressor and mesenteric arterial hyporesponsiveness to angiotensin II is an early event in haemorrhagic hypotension in anaesthetised rats. Cardiovasc Res. 1999 Oct;44(1):166-75. PubMed PMID: 10615400. 12: Heinemann A, Wachter CH, Peskar BA, Holzer P. Dilatation by angiotensin II of the rat femoral arterial bed in vivo via pressure/flow-induced release of nitric oxide and prostaglandins. Br J Pharmacol. 1997 Nov;122(6):975-84. PubMed PMID: 9401758; PubMed Central PMCID: PMC1565027.