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MedKoo Cat#: 591004 | Name: Clomacran

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clomacran is a biochemical.

Chemical Structure

Clomacran
Clomacran
CAS#5310-55-4 (free base)

Theoretical Analysis

MedKoo Cat#: 591004

Name: Clomacran

CAS#: 5310-55-4 (free base)

Chemical Formula: C18H21ClN2

Exact Mass: 300.1393

Molecular Weight: 300.83

Elemental Analysis: C, 71.87; H, 7.04; Cl, 11.78; N, 9.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
22199-46-8 (phosphate) 5310-55-4 (free base)
Synonym
Clomacran; Clomacrane
IUPAC/Chemical Name
9-Acridinepropanamine, 2-chloro-9,10-dihydro-N,N-dimethyl-
InChi Key
JFRLWWDJCFYFSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21ClN2/c1-21(2)11-5-7-14-15-6-3-4-8-17(15)20-18-10-9-13(19)12-16(14)18/h3-4,6,8-10,12,14,20H,5,7,11H2,1-2H3
SMILES Code
CN(C)CCCC1C2=C(C=CC=C2)NC3=CC=C(Cl)C=C13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Samara MT, Cao H, Helfer B, Davis JM, Leucht S. Chlorpromazine versus every other antipsychotic for schizophrenia: a systematic review and meta-analysis challenging the dogma of equal efficacy of antipsychotic drugs. Eur Neuropsychopharmacol. 2014 Jul;24(7):1046-55. doi: 10.1016/j.euroneuro.2014.03.012. Epub 2014 Apr 4. Review. PubMed PMID: 24766970. 2: Squires RF, Saederup E. Clozapine and several other antipsychotic/antidepressant drugs preferentially block the same 'core' fraction of GABA(A) receptors. Neurochem Res. 1998 Oct;23(10):1283-90. PubMed PMID: 9804284. 3: Torres Ruiz A, Galván Gómez L, Nieto D. [Treatment of schizophrenic patients with clomacran. A transcultural study (author's transl)]. Arch Neurobiol (Madr). 1981 Mar-Apr;44(2):117-24. Spanish. PubMed PMID: 7259415. 4: Torres-Ruiz A, Nieto D, Ban TA. An uncontrolled clinical study with clomacran in newly admitted schizophrenic patients. Psychopharmacol Bull. 1977 Jul;13(3):6-7. PubMed PMID: 329331. 5: Pecknold JC, Ban TA, Lehmann HE. A standard- (trifluoperazine) controlled clinical study with clomacran in newly admitted schizophrenic patients. Psychopharmacol Bull. 1977 Jul;13(3):14-5. PubMed PMID: 329322. 6: Fowler PJ, Zirkle CL, Macko E, Kaiser C, Sarau H, Tedeschi DH. Pharmacological evaluation of clomacran, a new potent psychotropic agent. Arzneimittelforschung. 1977;27(4):866-72. PubMed PMID: 17419. 7: Galvan L, Torres A, Nieto D. Proceedings: Clomacran in the treatment of schizophrenic patients--a comparison of two assessment methods. Psychopharmacol Bull. 1976 Jan;12(1):30-1. PubMed PMID: 1108081. 8: Pecknold JC, Ban TA, Lehmann HE, Climan M. Clomacran in the treatment of schizophrenic patients: a comparison of two assessment methods. Int J Clin Pharmacol Biopharm. 1975 Jun;11(4):299-303. PubMed PMID: 1099021. 9: Ban TA, Lehmann HE, Galvan L, Pecknold JC, Climan M. A transcultural study with clomacran: comparison of two assessment methods. Curr Ther Res Clin Exp. 1974 Sep;16(9):971-89. PubMed PMID: 4214672. 10: Rickels K, Perloff M, Perez LA, Pereira-Ogan JA, Kelly EA, Hesbacher PT. Clomacran in anxious neurotic outpatients: a controlled study. J Clin Pharmacol New Drugs. 1972 Jan;12(1):46-53. PubMed PMID: 4550225. 11: Case WG, Ryder BL, Dhopeshwarkar VP, Pereira-Ogan JA, Rickels K. Clomacran and chlorpromazine in psychotic outpatients: a controlled study. Curr Ther Res Clin Exp. 1971 Jun;13(6):337-43. PubMed PMID: 4996219. 12: Simpson GM. [Clomacran-phosphate against schizophrenia]. Munch Med Wochenschr. 1970 Oct 16;42:3. German. PubMed PMID: 5536267. 13: Nair KC, Chen CH. Clinical trial of clomacran phosphate (SKF-14336) in chronic psychotic male patients. Curr Ther Res Clin Exp. 1970 Jun;12(6):394-401. PubMed PMID: 4987347. 14: Lampe WT 2nd. Adverse effects with clomacran. J Clin Pharmacol J New Drugs. 1970 May-Jun;10(3):171-4. PubMed PMID: 5266631. 15: Irwin GM, Dodson GJ, Ravin LJ. Encapsulation of clomacran phosphate [2-chloro-9[3-(dimethylamino) propyl]acridan phosphate] I. Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine. J Pharm Sci. 1970 Apr;59(4):547-50. PubMed PMID: 5440686. 16: Lampe WT 2nd. A double blind study of clomacran. Curr Ther Res Clin Exp. 1969 May;11(5):300-6. PubMed PMID: 4977403. 17: Angus JW, Deutsch LJ, Edwards JG, Simpson GM. A double-blind comparison of the acridane derivative, clomacran phosphate and trifluoperazine in schizophrenia. Behav Neuropsychiatry. 1969 Apr;1(1):13-8. PubMed PMID: 4920977. 18: Edwards JG, Simpson GM. A trial of clomacran phosphate (SK&F 14,336) in mania. Curr Ther Res Clin Exp. 1969 Mar;11(3):115-7. PubMed PMID: 4976239.a