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MedKoo Cat#: 562717 | Name: DB772

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DB772 is a monocationic inhibitor of scrapie prion accumulation.

Chemical Structure

DB772
DB772
CAS#1451058-50-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 562717

Name: DB772

CAS#: 1451058-50-6 (HCl)

Chemical Formula: C20H16N4O

Exact Mass: 328.1324

Molecular Weight: 328.37

Elemental Analysis: C, 73.15; H, 4.91; N, 17.06; O, 4.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
433735-90-1 (free base) 1451058-50-6 (HCl)
Synonym
DB772; DB-772; DB 772;
IUPAC/Chemical Name
2-(5-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)furan-2-yl)-1H-benzo[d]imidazole
InChi Key
XDFQDDCYYZDDDY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16N4O/c1-2-4-16-15(3-1)23-20(24-16)18-10-9-17(25-18)13-5-7-14(8-6-13)19-21-11-12-22-19/h1-10H,11-12H2,(H,21,22)(H,23,24)
SMILES Code
C1(C2=CC=C(C3=CC=C(C4=NC5=C(C=CC=C5)N4)O3)C=C2)=NCCN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dinkel KD, Stanton JB, Boykin DW, Stephens CE, Madsen-Bouterse SA, Schneider DA. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82. doi: 10.1128/AAC.00811-16. Print 2016 Sep. PubMed PMID: 27381401; PubMed Central PMCID: PMC4997874. 2: Newcomer BW, Marley MS, Galik PK, Zhang Y, Riddell KP, Boykin DW, Kumar A, Kuhnt LA, Gard JA, Givens MD. Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus. Can J Vet Res. 2013 Jul;77(3):170-6. PubMed PMID: 24101792; PubMed Central PMCID: PMC3700441. 3: Newcomer BW, Neill JD, Marley MS, Ridpath JF, Givens MD. Mutations induced in the NS5B gene of bovine viral diarrhea virus by antiviral treatment convey resistance to the compound. Virus Res. 2013 Jun;174(1-2):95-100. doi: 10.1016/j.virusres.2013.03.007. Epub 2013 Mar 21. PubMed PMID: 23524138. 4: Stanton JB, Schneider DA, Dinkel KD, Balmer BF, Baszler TV, Mathison BA, Boykin DW, Kumar A. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. doi: 10.1371/journal.pone.0051173. Epub 2012 Nov 30. Erratum in: PLoS One. 2015;10(3):e0119084. PubMed PMID: 23226483; PubMed Central PMCID: PMC3511409. 5: Newcomer BW, Marley MS, Ridpath JF, Neill JD, Boykin DW, Kumar A, Givens MD. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96(2):127-9. doi: 10.1016/j.antiviral.2012.09.005. Epub 2012 Sep 14. PubMed PMID: 22985628. 6: Newcomer BW, Marley MS, Galik PK, Walz PH, Zhang Y, Riddell KP, Dykstra CC, Boykin DW, Kumar A, Cruz-Espindola C, Boothe DM, Joiner KS, Givens MD. Antiviral treatment of calves persistently infected with bovine viral diarrhoea virus. Antivir Chem Chemother. 2012 Jan 17;22(4):171-9. doi: 10.3851/IMP1903. PubMed PMID: 22182713. 7: Givens MD, Stringfellow DA, Dykstra CC, Riddell KP, Galik PK, Sullivan E, Robl J, Kasinathan P, Kumar A, Boykin DW. Prevention and elimination of bovine viral diarrhea virus infections in fetal fibroblast cells. Antiviral Res. 2004 Nov;64(2):113-8. PubMed PMID: 15498606.