Aconiazide | CAS# 13410-86-1

MedKoo Cat#: 571589 | Name: Aconiazide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aconiazide is an anti-tuberculosis prodrug.

Chemical Structure

Aconiazide

CAS#13410-86-1

Theoretical Analysis

MedKoo Cat#: 571589

Name: Aconiazide

CAS#: 13410-86-1

Chemical Formula: C15H13N3O4

Exact Mass: 299.0906

Molecular Weight: 299.29

Elemental Analysis: C, 60.20; H, 4.38; N, 14.04; O, 21.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Aconiazida

IUPAC/Chemical Name

Isonicotinic acid (o-(carboxymethoxy)benzylidene)hydrazide

InChi Key

MDFXJBQEWLCGHP-RQZCQDPDSA-N

InChi Code

InChI=1S/C15H13N3O4/c19-14(20)10-22-13-4-2-1-3-12(13)9-17-18-15(21)11-5-7-16-8-6-11/h1-9H,10H2,(H,18,21)(H,19,20)/b17-9+

SMILES Code

O=C(N/N=C/C1=CC=CC=C1OCC(O)=O)C2=CC=NC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 299.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: West RW, Kodell RL. A comparison of methods of benchmark-dose estimation for continuous response data. Risk Anal. 1999 Jun;19(3):453-9. PubMed PMID: 10765417. 2: Hothorn LA, Hauschke D. Identifying the maximum safe dose: a multiple testing approach. J Biopharm Stat. 2000 Feb;10(1):15-30. PubMed PMID: 10709798. 3: Bosch RJ, Wypij D, Ryan LM. A semiparametric approach to risk assessment for quantitative outcomes. Risk Anal. 1996 Oct;16(5):657-65. PubMed PMID: 8962516. 4: Hansen EB Jr, Dooley KL, Thompson HC Jr. High-performance liquid chromatographic analysis of the antituberculosis drugs aconiazide and isoniazid. J Chromatogr B Biomed Appl. 1995 Aug 18;670(2):259-66. PubMed PMID: 8548016. 5: Peloquin CA, James GT, Craig LD, Kim M, McCarthy EA, Iklé D, Iseman MD. Pharmacokinetic evaluation of aconiazide, a potentially less toxic isoniazid prodrug. Pharmacotherapy. 1994 Jul-Aug;14(4):415-23. PubMed PMID: 7937278. 6: Kodell RL, West RW. Upper confidence limits on excess risk for quantitative responses. Risk Anal. 1993 Apr;13(2):177-82. PubMed PMID: 8502790. 7: Held HR, Landi S. Binding of toxic metabolites of isoniazid by aconiazide. J Pharm Sci. 1980 Nov;69(11):1284-7. PubMed PMID: 7452457.