IUPAC/Chemical Name
1-Allyl-3,5-diethyl-6-chlorouracil
InChi Key
GPSWWJCFLZMBGB-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15ClN2O2/c1-4-7-14-9(12)8(5-2)10(15)13(6-3)11(14)16/h4H,1,5-7H2,2-3H3
SMILES Code
O=C(N1CC)N(CC=C)C(Cl)=C(CC)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
242.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Harada K, Okiyoneda T, Hashimoto Y, Oyokawa K, Nakamura K, Suico MA, Shuto T, Kai H. Curcumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticulin. Biochem Biophys Res Commun. 2007 Feb 9;353(2):351-6. Epub 2006 Dec 13. PubMed PMID: 17178109.
2: Kaul R, Hempel B, Kiefer G. Structure of a novel sulphur-containing metabolite of Acluracil (1-allyl-3,5-diethyl-6-chlorouracil). Xenobiotica. 1982 Aug;12(8):495-8. PubMed PMID: 7147995.
3: Kaul R, Hempel B, Kiefer G. 2-14C-1-Allyl-3,5-diethyl-6-chlorouracil I: Synthesis, absorption in human skin, excretion, distribution, and metabolism in rats and rabbits. J Pharm Sci. 1982 Aug;71(8):893-6. PubMed PMID: 7120091.
4: Kiefer G, Kaul R, Keppeler K, Hempel B. [Biotransformation of [2-14C]-1-alkyl-3,5-diethyl-6-chlorouracil and synthesis of some possible degradation products (author's transl)]. Arch Pharm (Weinheim). 1982 May;315(5):444-50. German. PubMed PMID: 7103697.
5: Kaul R, Kiefer G, Hempel B. [Identification of a third S-containing metabolite of 1-allyl-3,5-diethyl-6-chlorouracil and mechanism of formation of SCH3-metabolites (author's transl)]. Arzneimittelforschung. 1982;32(6):610-2. German. PubMed PMID: 7202365.
6: Hempel B. [Comparison of the accelerated stability test with the long-term stability of 1-allyl-3,5-diethyl-6-chlorouracil]. Pharm Acta Helv. 1982;57(2):34-6. German. PubMed PMID: 7071066.
7: Kaul R, Hempel B, Schäfer W. [Identification of two S-containing metabolites of 1-allyl-3,5-diethyl-6-chlorouracil in rabbit urine (author's transl)]. Arzneimittelforschung. 1976 Apr;26(4):489-99. German. PubMed PMID: 989004.
