Synonym
LSN3316612; LSN 3316612; LSN-3316612;
IUPAC/Chemical Name
N-(5-(((2S,4S)-4-((6-fluoropyridin-2-yl)oxy)-2-methylpiperidin-1-yl)methyl)thiazol-2-yl)acetamide
InChi Key
YJKMHISUTLWXQP-AAEUAGOBSA-N
InChi Code
1S/C17H21FN4O2S/c1-11-8-13(24-16-5-3-4-15(18)21-16)6-7-22(11)10-14-9-19-17(25-14)20-12(2)23/h3-5,9,11,13H,6-8,10H2,1-2H3,(H,19,20,23)/t11-,13-/m0/s1
SMILES Code
CC(NC1=NC=C(CN2[C@@H](C)C[C@@H](OC3=NC(F)=CC=C3)CC2)S1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
364.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lee JH, Veronese M, Liow JS, Morse CL, Montero Santamaria JA, Haskali MB, Zoghbi SS, Pike VW, Innis RB, Zanotti-Fregonara P. Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase. EJNMMI Res. 2021 Apr 1;11(1):35. doi: 10.1186/s13550-021-00780-z. PMID: 33796956; PMCID: PMC8017047.
2: Paul S, Haskali MB, Liow JS, Zoghbi SS, Barth VN, Kolodrubetz MC, Bond MR, Morse CL, Gladding RL, Frankland MP, Kant N, Slieker L, Shcherbinin S, Nuthall HN, Zanotti-Fregonara P, Hanover JA, Jesudason C, Pike VW, Innis RB. Evaluation of a PET Radioligand to Image O-GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse. J Nucl Med. 2019 Jan;60(1):129-134. doi: 10.2967/jnumed.118.213231. Epub 2018 Sep 13. PMID: 30213846; PMCID: PMC6354227.
