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MedKoo Cat#: 562669 | Name: Ppc-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ppc-1 is an anti-obesity agent. It shows mitochondrial uncoupling activity in vitro and anti-obesity activity in vivo. Ppc-1 is also an inhibitor of interleukin-2 (IL2) production in Jurkat cells.

Chemical Structure

Ppc-1
Ppc-1
CAS#1245818-17-0

Theoretical Analysis

MedKoo Cat#: 562669

Name: Ppc-1

CAS#: 1245818-17-0

Chemical Formula: C21H25NO4

Exact Mass: 355.1784

Molecular Weight: 355.43

Elemental Analysis: C, 70.96; H, 7.09; N, 3.94; O, 18.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ppc-1; Ppc 1; Ppc1;
IUPAC/Chemical Name
4-Methoxy-8-[(3-methyl-2-buten-1-yl)oxy]-2-quinolinecarboxylic acid 3-methyl-2-buten-1-yl ester
InChi Key
PBLQSFOIWOTFNY-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25NO4/c1-14(2)9-11-25-18-8-6-7-16-19(24-5)13-17(22-20(16)18)21(23)26-12-10-15(3)4/h6-10,13H,11-12H2,1-5H3
SMILES Code
O=C(C1=NC2=C(OC/C=C(C)/C)C=CC=C2C(OC)=C1)OC/C=C(C)\C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 28657476. 4: Ogura M, Kikuchi H, Suzuki T, Yamaki J, Homma MK, Oshima Y, Homma Y. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65. doi: 10.1016/j.bcp.2016.01.020. Epub 2016 Jan 28. PubMed PMID: 26827943. 5: Cheng G, Wang L, Lan H. Cloning of PEPC-1 from a C4 halophyte Suaeda aralocaspica without Kranz anatomy and its recombinant enzymatic activity in responses to abiotic stresses. Enzyme Microb Technol. 2016 Feb;83:57-67. doi: 10.1016/j.enzmictec.2015.11.006. Epub 2015 Nov 22. PubMed PMID: 26777251. 6: Willmore AM, Simón-Gracia L, Toome K, Paiste P, Kotamraju VR, Mölder T, Sugahara KN, Ruoslahti E, Braun GB, Teesalu T. Targeted silver nanoparticles for ratiometric cell phenotyping. Nanoscale. 2016 Apr 28;8(17):9096-101. doi: 10.1039/c5nr07928d. PubMed PMID: 26646247; PubMed Central PMCID: PMC4850089. 7: Deng H, Zhang LS, Zhang GQ, Zheng BQ, Liu ZJ, Wang Y. Evolutionary history of PEPC genes in green plants: Implications for the evolution of CAM in orchids. Mol Phylogenet Evol. 2016 Jan;94(Pt B):559-564. doi: 10.1016/j.ympev.2015.10.007. Epub 2015 Oct 19. PubMed PMID: 26493226. 8: Asher DE, Oros N, Krichmar JL. The Importance of Lateral Connections in the Parietal Cortex for Generating Motor Plans. PLoS One. 2015 Aug 7;10(8):e0134669. doi: 10.1371/journal.pone.0134669. eCollection 2015. PubMed PMID: 26252871; PubMed Central PMCID: PMC4529220. 9: Rozanov D, Cheltsov A, Sergienko E, Vasile S, Golubkov V, Aleshin AE, Levin T, Traer E, Hann B, Freimuth J, Alexeev N, Alekseyev MA, Budko SP, Bächinger HP, Spellman P. TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response. PLoS One. 2015 Jun 15;10(6):e0129566. doi: 10.1371/journal.pone.0129566. eCollection 2015. PubMed PMID: 26075913; PubMed Central PMCID: PMC4468210. 10: Azelmat J, Fiorito S, Genovese S, Epifano F, Grenier D. Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum. Med Chem. 2015;11(7):666-9. PubMed PMID: 25925558. 11: Suzuki T, Kikuchi H, Ogura M, Homma MK, Oshima Y, Homma Y. Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. PLoS One. 2015 Feb 10;10(2):e0117088. doi: 10.1371/journal.pone.0117088. eCollection 2015. PubMed PMID: 25668511; PubMed Central PMCID: PMC4323345. 12: Kikuchi H, Suzuki T, Ogura M, Homma MK, Homma Y, Oshima Y. Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities. Bioorg Med Chem. 2015 Jan 1;23(1):66-72. doi: 10.1016/j.bmc.2014.11.024. Epub 2014 Nov 22. PubMed PMID: 25496808. 13: Forbes N, Pallaoro A, Reich NO, Zasadzinski JA. Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near-Infra-Red Light. Part Part Syst Charact. 2014 Nov;31(11):1158-1167. doi: 10.1002/ppsc.201400035. Epub 2014 Jul 14. PubMed PMID: 29167602; PubMed Central PMCID: PMC5695930. 14: Costa AM, Nunes JC, Lima BN, Pedrosa C, Calado V, Torres AG, Pierucci AP. Effective stabilization of CLA by microencapsulation in pea protein. Food Chem. 2015 Feb 1;168:157-66. doi: 10.1016/j.foodchem.2014.07.016. Epub 2014 Jul 11. PubMed PMID: 25172695. 15: Rosnow JJ, Edwards GE, Roalson EH. Positive selection of Kranz and non-Kranz C4 phosphoenolpyruvate carboxylase amino acids in Suaedoideae (Chenopodiaceae). J Exp Bot. 2014 Jul;65(13):3595-607. doi: 10.1093/jxb/eru053. Epub 2014 Mar 5. PubMed PMID: 24600021; PubMed Central PMCID: PMC4085955. 16: Paoli EE, Ingham ES, Zhang H, Mahakian LM, Fite BZ, Gagnon MK, Tam S, Kheirolomoom A, Cardiff RD, Ferrara KW. Accumulation, internalization and therapeutic efficacy of neuropilin-1-targeted liposomes. J Control Release. 2014 Mar 28;178:108-17. doi: 10.1016/j.jconrel.2014.01.005. Epub 2014 Jan 13. PubMed PMID: 24434424; PubMed Central PMCID: PMC4079909. 17: Dube N, Shu JY, Dong H, Seo JW, Ingham E, Kheirolomoom A, Chen PY, Forsayeth J, Bankiewicz K, Ferrara KW, Xu T. Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers. Biomacromolecules. 2013 Oct 14;14(10):3697-705. doi: 10.1021/bm4010518. Epub 2013 Oct 3. PubMed PMID: 24050265; PubMed Central PMCID: PMC3923314. 18: Grishin AV, Iavorovskiĭ AG, Zhidkov IL, Charchian ÉR, Ivanova AG, Paliulina MV, Sitnichenko NV. [Sevoflurane optimal dosage estimation for myocardium pharmacological postconditioning: an experimental study]. Anesteziol Reanimatol. 2013 Mar-Apr;(2):41-4. Russian. PubMed PMID: 24000650. 19: Frikha M, Valencia DG, de Coca-Sinova A, Lázaro R, Mateos GG. Ileal digestibility of amino acids of unheated and autoclaved pea protein concentrate in broilers. Poult Sci. 2013 Jul;92(7):1848-57. doi: 10.3382/ps.2013-03007. PubMed PMID: 23776273. 20: Wilkie-Grantham RP, Matsuzawa S, Reed JC. Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein. J Biol Chem. 2013 May 3;288(18):12777-90. doi: 10.1074/jbc.M112.431320. Epub 2013 Mar 21. PubMed PMID: 23519470; PubMed Central PMCID: PMC3642323.