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MedKoo Cat#: 562661 | Name: NSC745885

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC745885 is a down-regulator of EZH2. It acts by inducing G2/M cell-cycle arrest of cancer cells and degradating p53 via proteasome-dependent and -independent pathways.

Chemical Structure

NSC745885
NSC745885
CAS#4219-52-7

Theoretical Analysis

MedKoo Cat#: 562661

Name: NSC745885

CAS#: 4219-52-7

Chemical Formula: C14H6N2O2S

Exact Mass: 266.0100

Molecular Weight: 266.27

Elemental Analysis: C, 63.15; H, 2.27; N, 10.52; O, 12.02; S, 12.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NSC745885; NSC-745885; NSC 745885;
IUPAC/Chemical Name
Anthra[1,2-c][1,2,5]thiadiazole-6,11-dione
InChi Key
SJPXIVLTCBBWKT-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H6N2O2S/c17-13-7-3-1-2-4-8(7)14(18)11-9(13)5-6-10-12(11)16-19-15-10/h1-6H
SMILES Code
O=C(C1=C2C=CC=C1)C3=C(C4=NSN=C4C=C3)C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 266.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dong G, Fang Y, Liu Y, Liu N, Wu S, Zhang W, Sheng C. Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors. Bioorg Med Chem Lett. 2017 May 1;27(9):1929-1933. doi: 10.1016/j.bmcl.2017.03.039. Epub 2017 Mar 18. PubMed PMID: 28351590. 2: Ali AA, Lee YR, Chen TC, Chen CL, Lee CC, Shiau CY, Chiang CH, Huang HS. Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination. PLoS One. 2016 Apr 21;11(4):e0154278. doi: 10.1371/journal.pone.0154278. eCollection 2016. PubMed PMID: 27100886; PubMed Central PMCID: PMC4839570. 3: Tang SH, Huang HS, Wu HU, Tsai YT, Chuang MJ, Yu CP, Huang SM, Sun GH, Chang SY, Hsiao PW, Yu DS, Cha TL. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo. Oncotarget. 2014 Nov 15;5(21):10342-55. PubMed PMID: 25431950; PubMed Central PMCID: PMC4279377. 4: Chen YW, Huang HS, Shieh YS, Ma KH, Huang SH, Hueng DY, Sytwu HK, Lin GJ. A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo. PLoS One. 2014 Aug 15;9(8):e104703. doi: 10.1371/journal.pone.0104703. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e113703. PubMed PMID: 25127132; PubMed Central PMCID: PMC4134221. 5: Chang YL, Lee HJ, Liu ST, Lin YS, Chen TC, Hsieh TY, Huang HS, Huang SM. Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin. Int J Biochem Cell Biol. 2011 Dec;43(12):1720-8. doi: 10.1016/j.biocel.2011.08.006. Epub 2011 Aug 12. PubMed PMID: 21856437. 6: Huang HS, Chen TC, Chen RH, Huang KF, Huang FC, Jhan JR, Chen CL, Lee CC, Lo Y, Lin JJ. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. doi: 10.1016/j.bmc.2009.09.033. Epub 2009 Sep 23. PubMed PMID: 19804981.

View History

Icosabutate

Icosabutate

Oglufanide TFA

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LY3325656

LY3325656

FSN-00382

FSN-00382

Ketimipramine Free Base

Ketimipramine Free Base

n-MCT

n-MCT