PKF050-638 | CAS#528893-52-9 | HIV-1 Rev inhibitor

MedKoo Cat#: 562642 | Name: PKF050-638

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PKF050-638 is a HIV-1 Rev inhibitor. It acts by interfering with the CRM1-mediated nuclear export and specifically inhibiting Rev-dependent luciferase reporter gene expression.

Chemical Structure

PKF050-638

CAS#528893-52-9

Theoretical Analysis

MedKoo Cat#: 562642

Name: PKF050-638

CAS#: 528893-52-9

Chemical Formula: C13H13ClN4O2

Exact Mass: 292.0727

Molecular Weight: 292.72

Elemental Analysis: C, 53.34; H, 4.48; Cl, 12.11; N, 19.14; O, 10.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PKF050-638; PKF050 638; PKF050638; PKF-050638; PKF 050638;

IUPAC/Chemical Name

(2Z)-3-[5-(2-Amino-5-chlorophenyl)-1H-1,2,4-triazol-1-yl]-2-propenoic acid ethyl ester

InChi Key

QWVNYBWNXRRADG-WAYWQWQTSA-N

InChi Code

InChI=1S/C13H13ClN4O2/c1-2-20-12(19)5-6-18-13(16-8-17-18)10-7-9(14)3-4-11(10)15/h3-8H,2,15H2,1H3/b6-5-

SMILES Code

O=C(OCC)/C=C\N1N=CN=C1C2=CC(Cl)=CC=C2N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 292.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gravina GL, Senapedis W, McCauley D, Baloglu E, Shacham S, Festuccia C. Nucleo-cytoplasmic transport as a therapeutic target of cancer. J Hematol Oncol. 2014 Dec 5;7:85. doi: 10.1186/s13045-014-0085-1. Review. PubMed PMID: 25476752; PubMed Central PMCID: PMC4272779. 2: Daelemans D, Afonina E, Nilsson J, Werner G, Kjems J, De Clercq E, Pavlakis GN, Vandamme AM. A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14440-5. Epub 2002 Oct 9. PubMed PMID: 12374846; PubMed Central PMCID: PMC137902.