Synonym
Fendosal; HP 129; HP129; HP-129; P 71-0129; P71-0129; P-71-0129
IUPAC/Chemical Name
Benzoic acid, 5-(4,5-dihydro-2-phenyl-3H-benz(e)indol-3-yl)-2-hydroxy-
InChi Key
HAWWPSYXSLJRBO-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H19NO3/c27-24-13-11-18(14-21(24)25(28)29)26-22-12-10-16-6-4-5-9-19(16)20(22)15-23(26)17-7-2-1-3-8-17/h1-9,11,13-15,27H,10,12H2,(H,28,29)
SMILES Code
O=C(O)C1=CC(N2C(C3=CC=CC=C3)=CC4=C2CCC5=CC=CC=C45)=CC=C1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
381.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wills RJ, Velagapudi RB, Puri SK, Yakatan GJ. The effect of food and antacid on the absorption of fendosal. Biopharm Drug Dispos. 1985 Jan-Mar;6(1):43-50. PubMed PMID: 3872688.
2: Lassman HB, Wilker JC, Anderson VB, Agnew MN, Allen RC, Novick WJ Jr. Fendosal (HP 129): a potent anti-inflammatory and analgesic compound. Agents Actions. 1978 Apr;8(3):209-17. PubMed PMID: 307337.
3: Desjardins PJ, Cooper SA, Ruderman CM, Gallegos LT, Reynolds DC, Kruger GO. The effects of fendosal, aspirin and placebo on postoperative dental pain. A dose-ranging and efficacy study. Pharmacotherapy. 1983 Jan-Feb;3(1):52-7. PubMed PMID: 6344034.
4: Warrander A, Metcalf R, Fromson JM. The disposition and metabolism of 5-(4,5-dihydro-2-phenylbenz[e]indol-3-yl)salicylic acid (fendosal) in the rat, mouse, rabbit, do, rhesus monkey, and man. Drug Metab Dispos. 1981 Mar-Apr;9(2):161-7. PubMed PMID: 6113117.
5: Forbes JA, Barkaszi BA, Ragland RN, Hankle JJ. Analgesic effect of fendosal, ibuprofen and aspirin in postoperative oral surgery pain. Pharmacotherapy. 1984 Nov-Dec;4(6):385-91. PubMed PMID: 6393076.
6: Gils A, Stassen JM, Nar H, Kley JT, Wienen W, Ries UJ, Declerck PJ. Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost. 2002 Jul;88(1):137-43. PubMed PMID: 12152654.
7: Lassman HB, Allen RC, Novick WJ Jr. Fendosal. N Engl J Med. 1981 Feb 26;304(9):546. PubMed PMID: 6969854.
8: Bloomfield SS, Barden TP, Mitchell J. Fendosal and aspirin in postpartum uterine pain. Clin Pharmacol Ther. 1978 Apr;23(4):390-6. PubMed PMID: 343968.
9: Hill HM, Chamberlain J, Hajdu P, Damm D. Rapid fluorimetric procedure for the analysis of fendosal in plasma and data following oral dosing. Biopharm Drug Dispos. 1980 Jan-Mar;1(3):97-102. PubMed PMID: 7448343.
10: Effland RC. Synthesis of carboxyarylindoles and benzofurans as nonsteroidal antiinflammatory agents. J Med Chem. 1977 Dec;20(12):1703-5. PubMed PMID: 592341.
