MedKoo Cat#: 555250 | Name: PF04471141 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-04471141 is a potent, selective inhibitor of the calcium-activated phosphodiesterase PDE1. (PDE1B IC50 = 35 nM).

Chemical Structure

PF04471141 HCl
PF04471141 HCl
CAS#1655498-17-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 555250

Name: PF04471141 HCl

CAS#: 1655498-17-1 (HCl)

Chemical Formula: C16H24ClN3O3

Exact Mass: 0.0000

Molecular Weight: 341.84

Elemental Analysis: C, 56.22; H, 7.08; Cl, 10.37; N, 12.29; O, 14.04

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
25mg USD 975.00 2 Weeks
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Related CAS #
1655578-12-3 (free base) 1655498-17-1 (HCl)
Synonym
PF04471141; PF 04471141; PF-04471141; PF04471141 HCl; PF04471141 hydrochloride.
IUPAC/Chemical Name
4-(3-Pentylamino)-6,7,8-trimethoxyquinazoline hydrochloride
InChi Key
QRHFQSUUJMOIHO-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H23N3O3.ClH/c1-6-10(7-2)19-16-11-8-12(20-3)14(21-4)15(22-5)13(11)17-9-18-16;/h8-10H,6-7H2,1-5H3,(H,17,18,19);1H
SMILES Code
COC1=C(OC)C(OC)=CC2=C(NC(CC)CC)N=CN=C12.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
PF-04471141 is a potent, selective inhibitor of the calcium-activated phosphodiesterase PDE1.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 341.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Zhang L, Bouadjel K, Manoury B, Vandecasteele G, Fischmeister R, Leblais V. Cyclic nucleotide signalling compartmentation by PDEs in cultured vascular smooth muscle cells. Br J Pharmacol. 2019 Jun;176(11):1780-1792. doi: 10.1111/bph.14651. Epub 2019 Apr 24. PMID: 30825186; PMCID: PMC6514293.