Dactylorhin B | CAS# 256459-36-6| xxxx

MedKoo Cat#: 581208 | Name: Dactylorhin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dactylorhin B is isolated from Coeloglossum viride. Dactylorhin B [short for bis(4-beta-D-glucopyranosyloxybenzyl)-2-beta-D-glucopyranosyl-2-isobutyltartrate (DHB)] is an active compound isolated from Coeloglossum viride. (L.) Hartm. var. bracteatum (Willd.) and may have neuroprotective effects. Dactylorhin B reduces toxic effects of beta-amyloid fragment (25-35) on neuron cells and isolated rat brain mitochondria. beta-amyloid is strongly implicated in Alzheimer's pathology, and mitochondria play an important role in neurodegenerative disorders.

Chemical Structure

Dactylorhin B

CAS#256459-36-6

Theoretical Analysis

MedKoo Cat#: 581208

Name: Dactylorhin B

CAS#: 256459-36-6

Chemical Formula: C40H57O23

Exact Mass: 905.3291

Molecular Weight: 905.87

Elemental Analysis: C, 53.04; H, 6.34; O, 40.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Dactylorhin B;

IUPAC/Chemical Name

Bis(4-beta-D-glucopyranosyloxybenzyl)-2-beta-D-glucopyranosyl-2-isobutyltartrate

InChi Key

JMNTZZACVOBZTI-YHWBMFKQSA-N

InChi Code

InChI=1S/C40H57O23/c1-17(2)11-40(56,35-31(50)28(47)25(44)22(12-41)61-35,39(55)58-16-19-5-9-21(10-6-19)60-38-33(52)30(49)27(46)24(14-43)63-38)34(53)36(54)57-15-18-3-7-20(8-4-18)59-37-32(51)29(48)26(45)23(13-42)62-37/h3-10,17,22-35,37-38,41-53,56H,11-16H2,1-2H3/t22-,23-,24-,25-,26-,27-,28+,29+,30+,31-,32-,33-,34?,35-,37-,38-/m1/s1

SMILES Code

OC(C(C(OCC1=CC=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C=C1)=O)O)(CC(C)C)([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(OCC4=CC=C(O[C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)C=C4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 905.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang D, Zhang Y, Liu G, Zhang J. Dactylorhin B reduces toxic effects of beta-amyloid fragment (25-35) on neuron cells and isolated rat brain mitochondria. Naunyn Schmiedebergs Arch Pharmacol. 2006 Nov;374(2):117-25. Epub 2006 Oct 5. PubMed PMID: 17021851. 2: Yue Z, Zi J, Zhu C, Lin S, Yang Y, Shi J. [Constituents of Gymnadenia conopsea]. Zhongguo Zhong Yao Za Zhi. 2010 Nov;35(21):2852-61. Chinese. PubMed PMID: 21322946. 3: Li M, Guo SX, Wang CL, Xiao PG. Quantitative determination of five glucosyloxybenzyl 2-isobutylmalates in the tubers of Gymnadenia conopsea and Coeloglossum viride var. bracteatum by HPLC. J Chromatogr Sci. 2009 Sep;47(8):709-13. PubMed PMID: 19772750. 4: Yang B, Li S, Zhang R, Wang Y, Shi J. [Quantitative analysis of four active constituents in Tibetan herb Gymnadenia conopsea by high-performance liquid chromatography]. Zhongguo Zhong Yao Za Zhi. 2009 Jul;34(14):1819-22. Chinese. PubMed PMID: 19894516. 5: Huang SY, Shi JG, Yang YC, Hu SL. [Studies on the chemical constituents of Coeloglossum viride (L.) Hartm. var. bracteatum (Willd.) Richter]. Yao Xue Xue Bao. 2002 Mar;37(3):199-203. Chinese. PubMed PMID: 12579762. 6: Cai M, Zhou Y, Gesang S, Bianba C, Ding LS. Chemical fingerprint analysis of rhizomes of Gymnadenia conopsea by HPLC-DAD-MSn. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Dec 5;844(2):301-7. Epub 2006 Aug 23. PubMed PMID: 16934540. 7: Huang SY, Li GQ, Shi JG, Mo SY. Chemical constituents of the rhizomes of Coeloglossum viride var. bracteatum. J Asian Nat Prod Res. 2004 Mar;6(1):49-61. PubMed PMID: 14989381. 8: Li M, Wang YF, Ma B, Liu GT, Zhang JJ. [Effect and mechanism of Coeloglossum viride var. bracteatum extract on scopolamine-induced deficits of learning and memory behavior of rodents]. Yao Xue Xue Bao. 2009 May;44(5):468-72. Chinese. PubMed PMID: 19618720.