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MedKoo Cat#: 341449 | Name: Astromicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Astromicin is a biochemical.

Chemical Structure

Astromicin
Astromicin
CAS#55779-06-1

Theoretical Analysis

MedKoo Cat#: 341449

Name: Astromicin

CAS#: 55779-06-1

Chemical Formula: C17H35N5O6

Exact Mass: 405.2587

Molecular Weight: 405.50

Elemental Analysis: C, 50.35; H, 8.70; N, 17.27; O, 23.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Astromicin; KW-1070; KW 1070; KW1070; XK 70-1; XK-70-1; XK70-1.
IUPAC/Chemical Name
4-Amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol
InChi Key
BIDUPMYXGFNAEJ-APGVDKLISA-N
InChi Code
InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1
SMILES Code
CO[C@H]1[C@@H](O)[C@H](N)[C@@H](O[C@H]2O[C@@H](CC[C@H]2N)[C@H](C)N)[C@H](O)[C@@H]1N(C)C(=O)CN
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Vector systems allowing efficient autonomous or integrative gene cloning in Micromonospora sp. strain 40027. Appl Environ Microbiol. 2003 Jun;69(6):3144-51. PubMed PMID: 12788709; PubMed Central PMCID: PMC161521. 5: Boehr DD, Jenkins SI, Wright GD. The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer. J Biol Chem. 2003 Apr 11;278(15):12873-80. Epub 2003 Feb 3. PubMed PMID: 12566434. 6: Liu M, Kato M, Hashimoto Y. Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit. Pharmacology. 2001;63(3):142-6. PubMed PMID: 11598419. 7: Udou T. [Functional characterization of a multiple-antibiotic resistant plasmid from clinical isolates of methicillin-resistant Staphylococcus aureus]. Kansenshogaku Zasshi. 2001 May;75(5):382-9. Japanese. PubMed PMID: 11424487. 8: Hotta K, Sunada A, Ikeda Y, Kondo S. Double stage activity in aminoglycoside antibiotics. J Antibiot (Tokyo). 2000 Oct;53(10):1168-74. PubMed PMID: 11132963. 9: Zhu CB, Sunada A, Ishikawa J, Ikeda Y, Kondo S, Hotta K. Role of aminoglycoside 6'-acetyltransferase in a novel multiple aminoglycoside resistance of an actinomycete strain #8: inactivation of aminoglycosides with 6'-amino group except arbekacin and neomycin. J Antibiot (Tokyo). 1999 Oct;52(10):889-94. PubMed PMID: 10604758. 10: Endo K. [Neuromuscular blocking properties of arbekacin, astromicin, isepamicin and netilmicin in the rabbit]. Jpn J Antibiot. 1999 Aug;52(8):554-61. Japanese. PubMed PMID: 10587880. 11: Hotta K, Ogata T, Ishikawa J, Okanishi M, Mizuno S, Morioka M, Naganawa H, Okami Y. Mechanism of multiple aminoglycoside resistance of kasugamycin-producing Streptomyces kasugaensis MB273: involvement of two types of acetyltransferases in resistance to astromicin group antibiotics. J Antibiot (Tokyo). 1996 Jul;49(7):682-8. PubMed PMID: 8784431. 12: Schwocho LR, Schaffner CP, Miller GH, Hare RS, Shaw KJ. Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1995 Aug;39(8):1790-6. PubMed PMID: 7486920; PubMed Central PMCID: PMC162827. 13: Rogers J, Davies J. The pseudodisaccharides: a novel class of group I intron splicing inhibitors. Nucleic Acids Res. 1994 Nov 25;22(23):4983-8. Erratum in: Nucleic Acids Res 1995 Feb 11;23(3):540. PubMed PMID: 7800490; PubMed Central PMCID: PMC523767. 14: Uematsu T. Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug. Int J Clin Pharmacol Ther Toxicol. 1993 Dec;31(12):606-10. PubMed PMID: 8314363. 15: Ohta T, Hasegawa M. Analysis of the self-defense gene (fmrO) of a fortimicin A (astromicin) producer, Micromonospora olivasterospora: comparison with other aminoglycoside-resistance-encoding genes. Gene. 1993 May 15;127(1):63-9. PubMed PMID: 8486289. 16: Ohta T, Dairi T, Hasegawa M. Characterization of two different types of resistance genes among producers of fortimicin-group antibiotics. J Gen Microbiol. 1993 Mar;139(3):591-9. PubMed PMID: 8473864. 17: Dairi T, Yamaguchi K, Hasegawa M. N-formimidoyl fortimicin A synthase, a unique oxidase involved in fortimicin A biosynthesis: purification, characterization and gene cloning. Mol Gen Genet. 1992 Dec;236(1):49-59. PubMed PMID: 1494350. 18: Dairi T, Ohta T, Hashimoto E, Hasegawa M. Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA. Mol Gen Genet. 1992 Dec;236(1):39-48. PubMed PMID: 1494349. 19: Uete T, Matsuo K, Uete G. Cross-resistance of clinical isolates of methicillin-resistant Staphylococcus aureus to aminoglycosides and fluoroquinolones. Jpn J Antibiot. 1992 Aug;45(8):943-8. PubMed PMID: 1433900. 20: Hasegawa M. A novel, highly efficient gene-cloning system in Micromonospora applied to the genetic analysis of fortimicin biosynthesis. Gene. 1992 Jun 15;115(1-2):85-91. PubMed PMID: 1612453.

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