Synonym
Xibenolol ; Xibenololum;
IUPAC/Chemical Name
1-((1,1-Dimethylethyl)amino)-3-(2,3-dimethylphenoxy)-2-propanol
InChi Key
RKUQLAPSGZJLGP-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H25NO2/c1-11-7-6-8-14(12(11)2)18-10-13(17)9-16-15(3,4)5/h6-8,13,16-17H,9-10H2,1-5H3
SMILES Code
OC(COC1=CC=CC(C)=C1C)CNC(C)(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
251.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Honma S, Ito T, Matsuki Y. [Stereoselective glucuronidation of beta-blocking agents, 1-tert-butylamino-3-(2,3-dimethylphenoxy)-2-propanol (D-32) and propranolol, in animals, in vivo and in vitro]. Yakugaku Zasshi. 1986 May;106(5):406-13. Japanese. PubMed PMID: 2876088.
2: Honma S, Ito T, Kambegawa A. Stereoselectivity in the metabolism of the beta-adrenergic blocking agent, (+/-)-1-tert-butylamino-3-(2,3-dimethylphenoxy)-2-propanol hydrochloride (xibenolol hydrochloride, D-32), in man. Chem Pharm Bull (Tokyo). 1985 Feb;33(2):760-8. PubMed PMID: 2861914.
3: Ishimori T, Shiratsuchi K, Izumi A, Himori N. [Antihypertensive action of adrenergic beta-receptor blockers and its effect on the entire sympathetic outflow in spontaneously hypertensive rats]. Nihon Yakurigaku Zasshi. 1982 Dec;80(6):463-9. Japanese. PubMed PMID: 6131020.
4: Himori N, Honma S, Izumi A, Ishimori T. Duration and selectivity in beta-adrenoceptor blocking action of a beta-adrenoceptor blocking drug, D-32 in conscious dogs. Naunyn Schmiedebergs Arch Pharmacol. 1981 Feb;316(1):19-23. PubMed PMID: 6116195.
