LC-SPDP Crosslinker, also known as SPDP-C6-NHS ester, is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional crosslinking reagent. The "long chain" LC-SPDP crosslinking reagent has a 15.7 angstrom spacer arm, compared to the shorter 6.8 angstrom spacer arm version of SPDP crosslinker. Often, due to steric hindrances, it is desirable to empirically test which of the two versions will work best in your specific application. LC-SPDP Crosslinker is useful for making Antibody Drug Conjugates (ADCs).
MedKoo Cat#: 571604
Name: LC-SPDP Crosslinker
CAS#: 158913-22-5
Chemical Formula: C18H23N3O5S2
Exact Mass: 425.1079
Molecular Weight: 425.52
Elemental Analysis: C, 50.81; H, 5.45; N, 9.88; O, 18.80; S, 15.07
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.0 | 117.50 |
The following data is based on the product molecular weight 425.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
