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MedKoo Cat#: 206966 | Name: AGI25696

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AGI-25696 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-25696 showed in vivo activity in MTAP null tumors. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many vendors mistakenly listed CAS#2201066-35-3 as its AGI25696. J. Med. Chem. 2021, 64, 8, 4430–4449 published AGI25696 structure (it is CAS#2201065-84-9).

Chemical Structure

AGI25696
AGI25696
CAS#2201065-84-9

Theoretical Analysis

MedKoo Cat#: 206966

Name: AGI25696

CAS#: 2201065-84-9

Chemical Formula: C28H20N4O

Exact Mass: 428.1637

Molecular Weight: 428.49

Elemental Analysis: C, 78.49; H, 4.70; N, 13.08; O, 3.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2201066-35-3 (de-methyl) 2201065-84-9
Synonym
AGI-25696; AGI 25696; AGI25696.
IUPAC/Chemical Name
5-methyl-2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
InChi Key
ZMZOMWGRJGQLDW-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H20N4O/c1-18-24(22-14-15-23-21(17-22)13-8-16-29-23)28(33)32-27(30-18)25(19-9-4-2-5-10-19)26(31-32)20-11-6-3-7-12-20/h2-17,30H,1H3
SMILES Code
O=C1C(C2=CC=C3N=CC=CC3=C2)=C(C)NC4=C(C5=CC=CC=C5)C(C6=CC=CC=C6)=NN14
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Pyrazolo[1,​5-​a]​pyrimidin-​7(4H)​-​ones as inhibitors of cellular metabolic processes and their preparation By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong From U.S. Pat. Appl. Publ. (2018), US 20180079753 A1 20180322. | Language: English, Database: CAPLUS 2. Preparation of pyrazolo[1,​5-​a]​pyrimidin-​7(4H)​-​ones as methionine adenosyltransferase 2A inhibitors for treatment of cancer By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong From PCT Int. Appl. (2018), WO 2018045071 A1 20180308. | Language: English, Database: CAPLUS