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MedKoo Cat#: 527870 | Name: MM-102
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MM-102 is a novel potent inhibitor of MLL1/WDR5 protein-protein interaction.

Chemical Structure

MM-102
CAS#1417329-24-8

Theoretical Analysis

MedKoo Cat#: 527870

Name: MM-102

CAS#: 1417329-24-8

Chemical Formula: C35H49F2N7O4

Exact Mass: 669.3814

Molecular Weight: 669.82

Elemental Analysis: C, 62.76; H, 7.37; F, 5.67; N, 14.64; O, 9.55

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 5,250.00 2 Weeks
2g USD 7,850.00 2 Weeks
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Related CAS #
1417329-24-8
Synonym
MM-102; MM102; MM 102
IUPAC/Chemical Name
N-[Bis(4-fluorophenyl)methyl]-1-[[(2S)-5-(diaminomethylideneamino)-2-[[2-ethyl-2-(2-methylpropanoylamino)butanoyl]amino]pentanoyl]amino]cyclopentane-1-carboxamide
InChi Key
RZKSQRIPRKWVBU-MHZLTWQESA-N
InChi Code
InChI=1S/C35H49F2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,40)/t27-/m0/s1
SMILES Code
O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCC/N=C(N)/N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MM-102 (HMTase Inhibitor IX) is a potent WDR5/MLL interaction inhibitor.
In vitro activity:
Evaluation of one such peptidomimetic, MM-102, in bone marrow cells transduced with MLL1-AF9 fusion construct shows that the compound effectively decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis. MM-102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins. Reference: J Am Chem Soc. 2013 Jan 16;135(2):669-82. https://pubmed.ncbi.nlm.nih.gov/23210835/
In vivo activity:
This study demonstrates that MLL1, WDR5, and trimethylated H3K4 (H3K4me3) were upregulated in renal tubular cells of cisplatin-induced AKI in mice, along with increased phosphorylation of p53 and decreased expression of E-cadherin. Administration of MM102, a selective MLL1/WDR5 complex inhibitor, improved renal function and attenuated tubular injury and apoptosis, while repressing MLL1, WDR5, and H3K4me3, dephosphorylating p53 and preserving E-cadherin. Reference: Cell Death Dis. 2022 Sep 6;13(9):770. https://pubmed.ncbi.nlm.nih.gov/36068197/
Solvent mg/mL mM comments
Solubility
DMF 30.0 44.79
DMF:PBS (pH 7.2) (1:1) 0.5 0.75
DMSO 62.5 93.31
Ethanol 100.0 149.29
Water 100.0 149.29
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 669.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Xiong Y, Wang Y, Ma L, Zhang Y, Qu X, Huang L, Wen X, Liu H, Zhang M, Zhang Y. Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization. J Cell Mol Med. 2021 Jan;25(1):297-308. doi: 10.1111/jcmm.16030. Epub 2020 Nov 17. PMID: 33201593; PMCID: PMC7810960. 2. Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135(2):669-82. doi: 10.1021/ja306028q. Epub 2012 Dec 27. PMID: 23210835; PMCID: PMC5180416. 3. Zhang C, Guan Y, Zou J, Yang X, Bayliss G, Zhuang S. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell Death Dis. 2022 Sep 6;13(9):770. doi: 10.1038/s41419-022-05104-0. PMID: 36068197; PMCID: PMC9448773. 4. Sun F, Mo L, Lan Y, Lu Q, Wu N, Song H. WDR5 drives the development of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition and cancer-associated fibroblasts formation. Pathol Res Pract. 2022 Aug 17;238:154076. doi: 10.1016/j.prp.2022.154076. Epub ahead of print. PMID: 36055087.
In vitro protocol:
1. Xiong Y, Wang Y, Ma L, Zhang Y, Qu X, Huang L, Wen X, Liu H, Zhang M, Zhang Y. Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization. J Cell Mol Med. 2021 Jan;25(1):297-308. doi: 10.1111/jcmm.16030. Epub 2020 Nov 17. PMID: 33201593; PMCID: PMC7810960. 2. Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135(2):669-82. doi: 10.1021/ja306028q. Epub 2012 Dec 27. PMID: 23210835; PMCID: PMC5180416.
In vivo protocol:
1. Zhang C, Guan Y, Zou J, Yang X, Bayliss G, Zhuang S. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell Death Dis. 2022 Sep 6;13(9):770. doi: 10.1038/s41419-022-05104-0. PMID: 36068197; PMCID: PMC9448773. 2. Sun F, Mo L, Lan Y, Lu Q, Wu N, Song H. WDR5 drives the development of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition and cancer-associated fibroblasts formation. Pathol Res Pract. 2022 Aug 17;238:154076. doi: 10.1016/j.prp.2022.154076. Epub ahead of print. PMID: 36055087.
1: Zhang Z, Zhai Y, Ma X, Zhang S, An X, Yu H, Li Z. Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer Embryos. Cell Physiol Biochem. 2018;45(4):1529-1540. doi: 10.1159/000487579. Epub 2018 Feb 16. PubMed PMID: 29466785. 2: Sun Z, Yu X, Chen W, Yang Q, Song Y, Zhou J, Jiang H. Costal Cartilage Assessment in Surgical Timing of Microtia Reconstruction. J Craniofac Surg. 2017 Sep;28(6):1521-1525. doi: 10.1097/SCS.0000000000003751. PubMed PMID: 28692518. 3: Weirich S, Kudithipudi S, Jeltsch A. Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex. Mol Oncol. 2017 Apr;11(4):373-387. doi: 10.1002/1878-0261.12041. Epub 2017 Mar 10. PubMed PMID: 28182322; PubMed Central PMCID: PMC5527479. 4: Venner C, Selton-Suty C, Huttin O, Erpelding ML, Aliot E, Juillière Y. Right ventricular dysfunction in patients with idiopathic dilated cardiomyopathy: Prognostic value and predictive factors. Arch Cardiovasc Dis. 2016 Apr;109(4):231-41. doi: 10.1016/j.acvd.2015.10.006. Epub 2016 Jan 15. PubMed PMID: 26782624. 5: Liu XP, Wang JF, Qian FY, Wang Y, Chen CJ, Shen YL. [Effect of Increasing Organic Loading Rate on the Formation and Stabilization Process of Aerobic Granular Sludge]. Huan Jing Ke Xue. 2015 Sep;36(9):3352-7. Chinese. PubMed PMID: 26717698. 6: Cai M, Bompada P, Atac D, Laakso M, Groop L, De Marinis Y. Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney. Biochem Biophys Res Commun. 2016 Jan 1;469(1):108-113. doi: 10.1016/j.bbrc.2015.11.079. Epub 2015 Nov 22. PubMed PMID: 26592666. 7: Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135(2):669-82. doi: 10.1021/ja306028q. Epub 2012 Dec 27. PubMed PMID: 23210835; PubMed Central PMCID: PMC5180416. 8: Chaluvadi S, Hotchkiss AT Jr, Call JE, Luchansky JB, Phillips JG, Liu L, Yam KL. Protection of probiotic bacteria in a synbiotic matrix following aerobic storage at 4 °C. Benef Microbes. 2012 Sep;3(3):175-87. doi: 10.3920/BM2012.0005. PubMed PMID: 22968408. 9: Priya SR, D'Cruz AK, Pai PS. Cut margins and disease control in oral cancers. J Cancer Res Ther. 2012 Jan-Mar;8(1):74-9. doi: 10.4103/0973-1482.95178. PubMed PMID: 22531518. 10: Ammar DA, Hamweyah KM, Kahook MY. Antioxidants Protect Trabecular Meshwork Cells From Hydrogen Peroxide-Induced Cell Death. Transl Vis Sci Technol. 2012 May 31;1(1):4. eCollection 2012. PubMed PMID: 24049700; PubMed Central PMCID: PMC3763872. 11: Wang S, Xiong J, Zhan C, Wang A, Chen Y, Jiang Q, Qiu Y. The anatomy of proximal femoral autografts for pelvic reconstruction: a cadaveric study. Surg Radiol Anat. 2012 May;34(4):305-9. doi: 10.1007/s00276-011-0914-7. Epub 2011 Dec 3. PubMed PMID: 22139395. 12: Zhang XJ, Chen DX, Xu HH, Zhao ML, Fang N, Du H, Zhou YS, Cheng ML, Yuan W, Jiang L, Xiao H, Wa QB, Liu LM, Liu J, Waalkes MP. Increased glycophorin A somatic cell variant frequency in arsenic-exposed patients of Guizhou, China. Toxicol Lett. 2006 Nov 1;167(1):47-53. Epub 2006 Sep 1. PubMed PMID: 17029826. 13: Burling D, Halligan S, Roddie ME, McQuillan J, Honeyfield L, Amin H, Dehmeshki J, Taylor SA, McFarland EG. Computed tomography colonography: automated diameter and volume measurement of colonic polyps compared with a manual technique--in vitro study. J Comput Assist Tomogr. 2005 May-Jun;29(3):387-93. PubMed PMID: 15891512. 14: Delić A, Kucinić M, Bucar M, Lazar B, Mrakovcić M. Morphometric and meristic characteristics of the goldside loach Sabanejewia balcanica (Cobitidae) in Central Croatia. Folia Biol (Krakow). 2003;51 Suppl:33-8. PubMed PMID: 15303337. 15: Matsunaga K, Morita I, Oguchi Y, Fujii T, Yoshikumi C, Nomoto K. [Competitive effect of PSK against the immunosuppressive effect induced in the sera of mice bearing syngeneic tumors]. Gan To Kagaku Ryoho. 1986 Dec;13(12):3461-7. Japanese. PubMed PMID: 3789757. 16: Toge T, Hamamoto S, Nakane H, Seto Y, Itagaki E, Hattori T. The enhancement of tumor cell susceptibility to macrophage binding and cytolysis by p-aminobenzoic acid-N-xyloside sodium salt (K-247). Int J Immunopharmacol. 1984;6(1):55-9. PubMed PMID: 6609891.

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