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MedKoo Cat#: 341310 | Name: Demethylbellidifolin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Demethylbellidifolin is a biochemcial.

Chemical Structure

Demethylbellidifolin
Demethylbellidifolin
CAS#2980-32-7

Theoretical Analysis

MedKoo Cat#: 341310

Name: Demethylbellidifolin

CAS#: 2980-32-7

Chemical Formula: C13H8O6

Exact Mass: 260.0321

Molecular Weight: 260.20

Elemental Analysis: C, 60.01; H, 3.10; O, 36.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Demethylbellidifolin; BRN 0286545; BRN-0286545; BRN0286545; CCRIS 3853.
IUPAC/Chemical Name
Xanthen-9-one, 1,3,5,8-tetrahydroxy-
InChi Key
MPXAWSABMVLIBU-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H8O6/c14-5-3-8(17)10-9(4-5)19-13-7(16)2-1-6(15)11(13)12(10)18/h1-4,14-17H
SMILES Code
O=C1C2=C(OC3=C1C(O)=CC=C3O)C=C(O)C=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 260.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang J, Yan H, Qu X, Zhou W. Validated LC-MS/MS method for quantitation of demethylbellidifolin in rat plasma and its application to pharmacokinetic and bioavailability studies. Biomed Chromatogr. 2018 Feb;32(2). doi: 10.1002/bmc.4043. Epub 2017 Aug 24. PubMed PMID: 28677899. 2: Wang Z, Wu Q, Yu Y, Yang C, Jiang H, Wang Q, Yang B, Kuang H. Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC-ESI-MS/MS. J Ethnopharmacol. 2015 Nov 4;174:261-9. doi: 10.1016/j.jep.2015.08.023. Epub 2015 Aug 20. PubMed PMID: 26297839. 3: Kesavan R, Potunuru UR, Nastasijević B, T A, Joksić G, Dixit M. Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts. PLoS One. 2013 Apr 18;8(4):e61393. doi: 10.1371/journal.pone.0061393. Print 2013. PubMed PMID: 23637826; PubMed Central PMCID: PMC3630200. 4: Lima B, Sánchez M, Luna L, Agüero MB, Zacchino S, Filippa E, Palermo JA, Tapia A, Feresin GE. Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean Slopes of San Juan Province, Argentina. Z Naturforsch C. 2012 Jan-Feb;67(1-2):29-38. PubMed PMID: 22486039. 5: Li JF, Lu GF, Zou YY. Demethylbellidifolin inhibits proliferation and activation of hepatic stellate cells. J Invest Surg. 2011;24(4):171-7. doi: 10.3109/08941939.2011.568593. PubMed PMID: 21675853. 6: Xu K, Shen J, Li F, Liu J, Liu G, Tan J, Tan G. [Determination of six active components in three species of genus Swertia by HPLC multiwavelength with detection]. Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1384-9. Chinese. PubMed PMID: 19771868. 7: Shi RZ, Li XH, Jia SJ, Fu QM, Chen YR, Chen J, Chen A, Li SX, Tan GS, Li YJ, Zhang GG. Demethylbellidifolin prevents nitroglycerin tolerance via improved aldehyde dehydrogenase 2 activity. Planta Med. 2009 Nov;75(14):1476-81. doi: 10.1055/s-0029-1185774. Epub 2009 Jun 16. PubMed PMID: 19533580. 8: Janković T, Savikin K, Menković N, Aljancić I, Leskovac A, Petrović S, Joksić G. Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes. Planta Med. 2008 Jun;74(7):736-40. doi: 10.1055/s-2008-1074524. Epub 2008 Apr 29. PubMed PMID: 18446672. 9: Jiang DJ, Jiang JL, Zhu HQ, Tan GS, Liu SQ, Xu KP, Li YJ. Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. J Ethnopharmacol. 2004 Aug;93(2-3):295-306. PubMed PMID: 15234768. 10: Jiang DJ, Jiang JL, Tan GS, Huang ZZ, Deng HW, Li YJ. Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level. Planta Med. 2003 Dec;69(12):1150-2. PubMed PMID: 14750034. 11: Jiang DJ, Tan GS, Zhou ZH, Xu KP, Ye F, Li YJ. Protective effects of demethylbellidifolin on myocardial ischemia-reperfusion injury in rats. Planta Med. 2002 Aug;68(8):710-3. PubMed PMID: 12221593. 12: Lacaille-Dubois MA, Galle K, Wagner H. Secoiridoids and xanthones from Gentianella nitida. Planta Med. 1996 Aug;62(4):365-8. PubMed PMID: 17252473.

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