Synonym
Polyoxyl 40 stearate; S 1004; S 1012; S 541.
IUPAC/Chemical Name
Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, octadecanoate
InChi Key
RFVNOJDQRGSOEL-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)23-19-18-21/h21H,2-19H2,1H3
SMILES Code
CCCCCCCCCCCCCCCCCC(OCCO)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent.
In vitro activity:
The aim of this study was to determine which POES has the greatest ability to enhance the growth of different mycobacterial species and how the HLB of each POES related to its effect on the growth of each species. This study found that POE(50)S produced the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and POE(30)S and POE(JL)S for species of mycobacteria other than M. tuberculosis (MOTT).
Reference: Tubercle. 1987 Sep;68(3):209-20. https://pubmed.ncbi.nlm.nih.gov/3448797/
In vivo activity:
The effects of PS40 (polyoxyethylene 40 stearate) on the antitumor activity of VBL were examined through 3-(4,5)-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay and multidrug-resistant tumor-bearing mice. Results of the transport experiments showed that PS40 reduced VBL efflux. The cytotoxicity of vinblastine to K562/ADR cells was significantly enhanced when the cells were cotreated with 100 or 150 microg/mL PS40. In vivo data revealed that average tumor volume and average tumor weight were significantly less in the VBL+PS40 group than in the VBL group. The inhibition rate for tumor growth was increased from 0.06 (VBL group) to 0.84 (VBL+PS40 group). These results suggest that PS40 may be a potentially useful adjuvant to enhance the therapeutic effects of P-gp substrates.
Reference: AAPS J. 2007 Oct 5;9(3):E329-35. https://pubmed.ncbi.nlm.nih.gov/18170979/
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMSO |
100.0 |
304.38 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
328.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Zhu S, Huang R, Hong M, Jiang Y, Hu Z, Liu C, Pei Y. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80. doi: 10.1016/j.ejps.2009.05.001. Epub 2009 May 12. PMID: 19442720.
2. Cutler RR, Wilson P, Clarke FV. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20. doi: 10.1016/0041-3879(87)90057-2. PMID: 3448797.
3. Luo L, Xu X, Shi B, Wu J, Hu Y. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. AAPS J. 2007 Oct 5;9(3):E329-35. doi: 10.1208/aapsj0903039. PMID: 18170979; PMCID: PMC2751484.
In vitro protocol:
1. Zhu S, Huang R, Hong M, Jiang Y, Hu Z, Liu C, Pei Y. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80. doi: 10.1016/j.ejps.2009.05.001. Epub 2009 May 12. PMID: 19442720.
2. Cutler RR, Wilson P, Clarke FV. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20. doi: 10.1016/0041-3879(87)90057-2. PMID: 3448797.
In vivo protocol:
1. Luo L, Xu X, Shi B, Wu J, Hu Y. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. AAPS J. 2007 Oct 5;9(3):E329-35. doi: 10.1208/aapsj0903039. PMID: 18170979; PMCID: PMC2751484.
1: Sato MR, Oshiro Junior JA, Machado RT, de Souza PC, Campos DL, Pavan FR, da Silva PB, Chorilli M. Nanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis. Drug Des Devel Ther. 2017 Mar 20;11:909-921. doi: 10.2147/DDDT.S127048. eCollection 2017. PubMed PMID: 28356717; PubMed Central PMCID: PMC5367736.
2: Kirilov P, Tran VH, Ducrotté-Tassel A, Salvi JP, Perrot S, Haftek M, Boulieu R, Pirot F. Ex-Vivo percutaneous absorption of enrofloxacin: Comparison of LMOG organogel vs. pentravan cream. Int J Pharm. 2016 Feb 10;498(1-2):170-7. doi: 10.1016/j.ijpharm.2015.12.018. Epub 2015 Dec 11. PubMed PMID: 26688043.
3: Nozawa K, Iwao Y, Noguchi S, Itai S. Effect of surfactants or a water soluble polymer on the crystal transition of clarithromycin during a wet granulation process. Int J Pharm. 2015 Nov 10;495(1):204-217. doi: 10.1016/j.ijpharm.2015.08.080. Epub 2015 Sep 7. PubMed PMID: 26325306.
4: Patel S, Garapati C, Chowdhury P, Gupta H, Nesamony J, Nauli S, Boddu SH. Development and evaluation of dexamethasone nanomicelles with potential for treating posterior uveitis after topical application. J Ocul Pharmacol Ther. 2015 May;31(4):215-27. doi: 10.1089/jop.2014.0152. Epub 2015 Apr 3. PubMed PMID: 25839185.
5: Ren X, Mao X, Cao L, Xue K, Si L, Qiu J, Schimmer AD, Li G. Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo. Eur J Pharm Sci. 2009 Mar 2;36(4-5):401-11. doi: 10.1016/j.ejps.2008.11.002. Epub 2008 Nov 8. PubMed PMID: 19041719.
6: Chen DY, Liu LM, Xie QD, Xu L, Huang TH. In vitro and in vivo studies evaluating antisemen antibodies as a potential spermicidal agent in hamsters. Fertil Steril. 2009 Sep;92(3):1116-23. doi: 10.1016/j.fertnstert.2008.07.1748. Epub 2008 Oct 4. PubMed PMID: 18835604.
7: Sintov AC, Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J Control Release. 2004 Mar 5;95(2):173-83. PubMed PMID: 14980766.
8: De Santis A, Fabris L, Fontani F, Taccani F, Zorzetto C. [Polyoxyl 40 stearate]. Boll Chim Farm. 1970 Sep;109(9):503. Italian. PubMed PMID: 5499459.
