MedKoo Cat#: 464054 | Name: Linearmycin B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Linearmycin B is a polyene antibiotic that has been found in Streptomyces. It induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.

Chemical Structure

Linearmycin B
Linearmycin B
CAS#182291-65-2

Theoretical Analysis

MedKoo Cat#: 464054

Name: Linearmycin B

CAS#: 182291-65-2

Chemical Formula: C66H103NO16

Exact Mass: 1165.7277

Molecular Weight: 1166.54

Elemental Analysis: C, 67.96; H, 8.90; N, 1.20; O, 21.94

Price and Availability

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500µg USD 500.00 Back order
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Related CAS #
No Data
Synonym
Linearmycin B; Linearmycin-B;
IUPAC/Chemical Name
(2E,4E,6E,8E,10E,14E,20E,22E,24E,26E,28E,40E,50E,54E)-62-amino-17,19,31,35,37,39,43,45,47,49,53,57,59-tridecahydroxy-2,16,18,32-tetramethyl-33-oxodohexaconta-2,4,6,8,10,14,20,22,24,26,28,40,50,54-tetradecaenoic acid
InChi Key
DHFLEVLIHWJIAE-OTPULODUSA-N
InChi Code
InChI=1S/C66H103NO16/c1-48(29-21-17-13-9-6-5-7-10-14-18-22-30-49(2)66(82)83)65(81)51(4)63(79)39-24-20-16-12-8-11-15-19-23-38-62(78)50(3)64(80)47-61(77)46-60(76)44-56(72)36-27-35-55(71)43-59(75)45-58(74)42-54(70)34-26-32-52(68)31-25-33-53(69)41-57(73)37-28-40-67/h5-12,14-16,18-27,29-31,34,36,39,48,50-63,65,68-79,81H,13,17,28,32-33,35,37-38,40-47,67H2,1-4H3,(H,82,83)/b7-5+,9-6+,12-8+,14-10+,15-11+,20-16+,22-18+,23-19+,29-21+,31-25+,34-26+,36-27+,39-24+,49-30+
SMILES Code
NCCCC(CC(C/C=C/C(C/C=C/C(CC(CC(CC(C/C=C/C(O)CC(CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(C(C(C(/C=C/CC/C=C/C=C/C=C/C=C/C=C(C(O)=O)\C)C)O)C)O)=O)O)O)O)O)O)O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 1,166.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Stubbendieck RM, Brock DJ, Pellois JP, Gill JJ, Straight PD. Linearmycins are lytic membrane-targeting antibiotics. J Antibiot (Tokyo). 2018 Mar;71(3):372-381. doi: 10.1038/s41429-017-0005-z. Epub 2018 Jan 18. PMID: 29348524. 2: Hoefler BC, Stubbendieck RM, Josyula NK, Moisan SM, Schulze EM, Straight PD. A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology. Cell Chem Biol. 2017 Oct 19;24(10):1238-1249.e7. doi: 10.1016/j.chembiol.2017.08.008. Epub 2017 Sep 14. PMID: 28919037. 3: Stubbendieck RM, Straight PD. Linearmycins Activate a Two-Component Signaling System Involved in Bacterial Competition and Biofilm Morphology. J Bacteriol. 2017 Aug 22;199(18):e00186-17. doi: 10.1128/JB.00186-17. PMID: 28461449; PMCID: PMC5573067.