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MedKoo Cat#: 330126 | Name: Cinepazide maleate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cinepazide is a vasodilator used for the treatment of cardiovascular, cerebrovascular, and peripheral vascular diseases. Cinepazide acts as a potentiator of adenosine A2 receptors and has also been characterized as a calcium channel blocker.

Chemical Structure

Cinepazide maleate
Cinepazide maleate
CAS#26328-04-1 (maleate)

Theoretical Analysis

MedKoo Cat#: 330126

Name: Cinepazide maleate

CAS#: 26328-04-1 (maleate)

Chemical Formula: C26H35N3O9

Exact Mass: 0.0000

Molecular Weight: 533.58

Elemental Analysis: C, 58.53; H, 6.61; N, 7.88; O, 26.99

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
100mg USD 450.00 2 Weeks
250mg USD 750.00 2 Weeks
500mg USD 1,050.00 2 Weeks
1g USD 1,650.00 2 Weeks
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Related CAS #
23887-46-9 (free base) 88197-48-2 (mesylate) 26328-04-1 (maleate)
Synonym
Cinepazide maleate; Cinepazide; MD 67350; MD-67350; MD67350; NSC 291562; NSC-291562; NSC291562; Brendil; Vasodistal
IUPAC/Chemical Name
1-[(1-Pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazine Maleate
InChi Key
XSTJTOKYCAJVMJ-GVTSEVKNSA-N
InChi Code
InChI=1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-
SMILES Code
O=C(N1CCN(CC(N2CCCC2)=O)CC1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3.O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 533.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liao X, Zhang Y, Xie YM, Liu Y, Yi DH, Zhang YL, Chen F. [Analysis of Diemailing Kudiezi injection use in real world in 7 189 patients with cerebral infarction]. Zhongguo Zhong Yao Za Zhi. 2016 Dec;41(23):4442-4450. doi: 10.4268/cjcmm20162324. Chinese. PubMed PMID: 28933125. 2: Hu W, Chao Y, Geng X. Neuroprotective strategies for patients with acute myocardial infarction combined with hypoxic ischemic encephalopathy in the ICU. Hellenic J Cardiol. 2017 Nov - Dec;58(6):427-431. doi: 10.1016/j.hjc.2016.12.006. Epub 2017 Jan 5. PubMed PMID: 28065791. 3: Li Y, Zhang T, Zhang X, Zou W, Gong X, Fu J. Cinepazide Maleate Improves Cognitive Function and Protects Hippocampal Neurons in Diabetic Rats with Chronic Cerebral Hypoperfusion. Biol Pharm Bull. 2017 Mar 1;40(3):249-255. doi: 10.1248/bpb.b16-00567. Epub 2016 Dec 17. PubMed PMID: 27990002. 4: Li YY, Cheng H, Xie YM. [Real world study of Dengzhan xixin injection in treatment of cerebral infarction with medication]. Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(18):3551-4. Chinese. PubMed PMID: 25532393. 5: Cui JF, Yang W, Xie YM, Sun Y, Zhuang Y, Wang YY. [Real-world analysis of concurrent diseases and medicine use among patients with insomnia]. Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(18):3519-26. Chinese. PubMed PMID: 25532388. 6: Luo YH, Xie YM, Yang W, Wang YY, You L, Zhuang Y. [Analysis of clinical use of shuxuening injection in treatment of cerebral infarction based on real world]. Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(18):3499-503. Chinese. PubMed PMID: 25532384. 7: Zhao J, Song Y, Wang H, Sun Y, Liu M, Lu C, Li Y, Wang S, Zhu X, Hai W, Wen A, Jia Y. High performance liquid chromatographic method for the determination of cinepazide maleate and its application to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:105-9. doi: 10.1016/j.jchromb.2014.02.038. Epub 2014 Mar 4. PubMed PMID: 24674989. 8: Zhao J, Bai Y, Zhang C, Zhang X, Zhang YX, Chen J, Xiong L, Shi M, Zhao G. Cinepazide maleate protects PC12 cells against oxygen-glucose deprivation-induced injury. Neurol Sci. 2014 Jun;35(6):875-81. doi: 10.1007/s10072-013-1618-z. Epub 2013 Dec 29. PubMed PMID: 24374788. 9: Zhu Y, Zhang G, Zhao J, Li D, Yan X, Liu J, Liu X, Zhao H, Xia J, Zhang X, Li Z, Zhang B, Guo Z, Feng L, Zhang Z, Qu F, Zhao G. Efficacy and safety of mildronate for acute ischemic stroke: a randomized, double-blind, active-controlled phase II multicenter trial. Clin Drug Investig. 2013 Oct;33(10):755-60. doi: 10.1007/s40261-013-0121-x. PubMed PMID: 23949899. 10: Shah SP, Chaudhry GM. Intracranial hemorrhage as a complication of dobutamine stress echocardiography: case report and review of the literature. Echocardiography. 2012 May;29(5):E119-21. doi: 10.1111/j.1540-8175.2011.01623.x. Review. PubMed PMID: 22537238. 11: Ibáñez L, Vidal X, Ballarín E, Laporte JR. Population-based drug-induced agranulocytosis. Arch Intern Med. 2005 Apr 25;165(8):869-74. PubMed PMID: 15851637. 12: Segbena A, Buguet A, Sangare A. [Sickle cell disease and depression: preliminary study using the Hamilton rating scale for depression]. Med Trop (Mars). 1994;54(1):47-52. French. PubMed PMID: 8196526. 13: Kelly JP, Kaufman DW, Shapiro S. Risks of agranulocytosis and aplastic anemia in relation to the use of cardiovascular drugs: The International Agranulocytosis and Aplastic Anemia Study. Clin Pharmacol Ther. 1991 Mar;49(3):330-41. PubMed PMID: 1672513. 14: Hirashima K, Yoshida Y, Asano S, Takaku F, Omine M, Furusawa S, Abe T, Abe T, Dohy H, Tajiri M, et al. Clinical effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on various types of neutropenia including cyclic neutropenia. Biotherapy. 1991;3(4):297-307. PubMed PMID: 1723891. 15: Laporte JR, Capellà D, Juan J. Agranulocytosis induced by cinepazide. Eur J Clin Pharmacol. 1990;38(4):387-8. PubMed PMID: 2344862. 16: Yamamoto M, Shimizu M, Kawabata S. Cerebral vasodilators potentiate the anti-anoxic activity of indeloxazine hydrochloride, a new cerebral activator. Neuropharmacology. 1989 Mar;28(3):313-7. PubMed PMID: 2725854. 17: Marteau P, Ballet F, Chrétien Y, Rey C, Jaillon P, Poupon R. Effect of vasodilators on hepatic microcirculation: a study of the inhibition of norepinephrine-induced vasoconstriction in the isolated perfused rat liver. Hepatology. 1988 Mar-Apr;8(2):228-31. PubMed PMID: 3356403. 18: Yamamoto M, Shimizu M. Effects of indeloxazine hydrochloride (YM-08054) on anoxia. Arch Int Pharmacodyn Ther. 1987 Apr;286(2):272-81. PubMed PMID: 3592867. 19: Chague F, Sgro C, Caillot D, Guy H, Portier C, Louis P, Escousse A. [Agranulocytosis caused by cinepazide maleate. 2 case reports]. Therapie. 1987 Jan-Feb;42(1):67. French. PubMed PMID: 3590073. 20: Miwa S, Fujiwara M, Lee K, Fujiwara M. The effects of cinepazide on the content, biosynthesis and turnover of noradrenaline, dopamine and 5-hydroxytryptamine in the rat brain under room air and hypoxia. Jpn J Pharmacol. 1986 May;41(1):109-15. PubMed PMID: 2426499.