VO-OHpic | CAS#476310-60-8 | PTEN inhibitor

MedKoo Cat#: 562481 | Name: VO-OHpic

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VO-OHpic is a vanadium-containing compound that inhibits protein tyrosine phosphatases (PTPs), which play a key role in regulating cellular signaling pathways. The compound features a vanadium (VO) center coordinated with a hydroxylated picolinic acid ligand, allowing selective modulation of cellular processes such as growth, differentiation, and apoptosis. VO-OHpic is being studied for its potential therapeutic applications in diseases like cancer and diabetes, where PTP dysregulation contributes to pathogenesis.

Chemical Structure

VO-OHpic

CAS#476310-60-8

Theoretical Analysis

MedKoo Cat#: 562481

Name: VO-OHpic

CAS#: 476310-60-8

Chemical Formula: C12H15N2O11V

Exact Mass: 414.0115

Molecular Weight: 414.19

Elemental Analysis: C, 34.80; H, 3.65; N, 6.76; O, 42.49; V, 12.30

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 230.00
10mg	USD 360.00
25mg	USD 700.00

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Related CAS #

No Data

Synonym

VO-OHpic; VO OHpic; VOOHpic;

IUPAC/Chemical Name

Hydroxy(oxo)vanadium 3-hydroxypyridine-2-carboxylic acid complex trihydrate

InChi Key

HCJXRYXYWPOIGP-UHFFFAOYSA-K

InChi Code

InChI=1S/2C6H5NO3.4H2O.O.V/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;/h2*1-3,8H,(H,9,10);4*1H2;;/q;;;;;;;+3/p-3

SMILES Code

O=[V](OC(C1=NC=CC=C1O)=O)(O)OC(C2=NC=CC=C2O)=O.O.O.O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 414.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 37857485; PMCID: PMC10727119. 7: Johnson AM, Jose S, Palakkott AR, Khan FB, Jayabalan N, Kizhakkayil J, AlNaqbi SAA, Scott MG, Ayoub MA, Gordon R, Saminathan H. Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events. J Neuroimmune Pharmacol. 2023 Sep;18(3):462-475. doi: 10.1007/s11481-023-10077-8. Epub 2023 Aug 17. PMID: 37589761. 8: Wu B, Shi L, Wu Y. PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice. Int J Mol Sci. 2023 Jun 9;24(12):9954. doi: 10.3390/ijms24129954. PMID: 37373102; PMCID: PMC10298298. 9: Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W. PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway. Aging (Albany NY). 2023 Mar 24;15(6):2275-2292. doi: 10.18632/aging.204612. Epub 2023 Mar 24. 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PTEN inhibitor attenuates cardiac fibrosis by regulating the M2 macrophage phenotype via the PI3K/AKT/TGF-β/Smad 2/3 signaling pathway. Int J Cardiol. 2022 Jun 1;356:88-96. doi: 10.1016/j.ijcard.2022.04.007. Epub 2022 Apr 5. PMID: 35395283. 14: Chen J, Sun J, Wang Q, Du Y, Cheng J, Yi J, Xie B, Jin S, Chen G, Wang L, Wang X, Wei H. Systemic Deficiency of PTEN Accelerates Breast Cancer Growth and Metastasis. Front Oncol. 2022 Mar 18;12:825484. doi: 10.3389/fonc.2022.825484. PMID: 35372075; PMCID: PMC8971716. 15: Han X, Zhang YL, Lin QY, Li HH, Guo SB. ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway. Cell Biol Toxicol. 2023 Oct;39(5):2113-2131. doi: 10.1007/s10565-022-09699-0. Epub 2022 Feb 26. PMID: 35218467; PMCID: PMC10547847. 16: Wei S, Sun J, Li Y, Xu K, Wang M, Zhang Y. 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