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MedKoo Cat#: 562417 | Name: SMA-12b

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SMA-12b is an inhibitor of IL-1.

Chemical Structure

SMA-12b
SMA-12b
CAS#1496553-39-9

Theoretical Analysis

MedKoo Cat#: 562417

Name: SMA-12b

CAS#: 1496553-39-9

Chemical Formula: C13H22INO2S

Exact Mass:

Molecular Weight: 383.28

Elemental Analysis: C, 40.74; H, 5.79; I, 33.11; N, 3.65; O, 8.35; S, 8.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SMA-12b; SMA 12b; SMA12b;
IUPAC/Chemical Name
N,N,N-Trimethyl-2-[[(4-methylphenyl)methyl]sulfonyl]-ethanaminium iodide
InChi Key
HWCJFPAHNSHXPO-UHFFFAOYSA-M
InChi Code
InChI=1S/C13H22NO2S.HI/c1-12-5-7-13(8-6-12)11-17(15,16)10-9-14(2,3)4;/h5-8H,9-11H2,1-4H3;1H/q+1;/p-1
SMILES Code
O=S(CC[N+](C)(C)C)(CC1=CC=C(C)C=C1)=O.[I-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rzepecka J, Pineda MA, Al-Riyami L, Rodgers DT, Huggan JK, Lumb FE, Khalaf AI, Meakin PJ, Corbet M, Ashford ML, Suckling CJ, Harnett MM, Harnett W. Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. J Autoimmun. 2015 Jun;60:59-73. doi: 10.1016/j.jaut.2015.04.005. Epub 2015 May 11. PubMed PMID: 25975491; PubMed Central PMCID: PMC4459730.

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