Small cardioactive peptide B | CAS#84746-43-0 | neurally active peptide

MedKoo Cat#: 597609 | Name: Small cardioactive peptide B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Small cardioactive peptide B is a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.

Chemical Structure

Small cardioactive peptide B

CAS#84746-43-0

Theoretical Analysis

MedKoo Cat#: 597609

Name: Small cardioactive peptide B

CAS#: 84746-43-0

Chemical Formula: C52H80N14O11S2

Exact Mass: 1140.5572

Molecular Weight: 1141.41

Elemental Analysis: C, 54.72; H, 7.06; N, 17.18; O, 15.42; S, 5.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Small cardioactive peptide B; SCPB; Met-asn-tyr-leu-ala-phe-pro-arg-met-NH2;

IUPAC/Chemical Name

(S)-N1-((S)-1-(((S)-1-(((S)-1-(((S)-1-((S)-2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-2-((S)-2-amino-4-(methylthio)butanamido)succinamide

InChi Key

IDATZUYVZKJKRE-SXMXEBDWSA-N

InChi Code

InChI=1S/C52H80N14O11S2/c1-29(2)25-37(63-48(74)38(26-32-15-17-33(67)18-16-32)64-49(75)39(28-42(54)68)62-45(71)34(53)19-23-78-4)47(73)59-30(3)44(70)65-40(27-31-11-7-6-8-12-31)51(77)66-22-10-14-41(66)50(76)61-36(13-9-21-58-52(56)57)46(72)60-35(43(55)69)20-24-79-5/h6-8,11-12,15-18,29-30,34-41,67H,9-10,13-14,19-28,53H2,1-5H3,(H2,54,68)(H2,55,69)(H,59,73)(H,60,72)(H,61,76)(H,62,71)(H,63,74)(H,64,75)(H,65,70)(H4,56,57,58)/t30-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1

SMILES Code

CSCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H]1N(C([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CC(N)=O)NC([C@H](CCSC)N)=O)=O)=O)=O)=O)=O)CCC1)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,141.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cawthorpe DR, Rosenberg J, Colmers WF, Lukowiak K, Drummond GI. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24. PubMed PMID: 4075267. 2: Bravarenko NI. [The effect of the small cardioactive peptide (b) on synaptic transmission efficiency and on the excitability of command neurons in the defensive behavior of the edible snail]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 Jan-Feb;41(1):107-12. Russian. PubMed PMID: 1647577. 3: Norekian TP, Satterlie RA. Small cardioactive peptide B increases the responsiveness of the neural system underlying prey capture reactions in the pteropod mollusc, Clione limacina. J Exp Zool. 1994 Oct 1;270(2):136-47. PubMed PMID: 7999153. 4: Acosta-Urquidi J. Modulation of calcium current and diverse K+ currents in identified Hermissenda neurons by small cardioactive peptide B. J Neurosci. 1988 May;8(5):1694-703. PubMed PMID: 3367217. 5: Ferretti ME, Sonetti D, Pareschi MC, Biondi C. Effects of the small cardioactive peptide B (SCPB) on adenylate cyclase of the central nervous system and peripheral organs of the freshwater snail Planorbarius corneus. Neurochem Int. 1993 May;22(5):479-86. PubMed PMID: 8387365. 6: Bravarenko NI. Influence of small cardioactive peptide (b) on the efficiency of synaptic transmission and the excitability of command neurons of the defensive behavior of the edible snail. Neurosci Behav Physiol. 1992 Mar-Apr;22(2):148-52. PubMed PMID: 1328927. 7: Mahon AC, Lloyd PE, Weiss KR, Kupfermann I, Scheller RH. The small cardioactive peptides A and B of Aplysia are derived from a common precursor molecule. Proc Natl Acad Sci U S A. 1985 Jun;82(11):3925-9. PubMed PMID: 3858852; PubMed Central PMCID: PMC397902. 8: Settembrini BP, Villar MJ. FMRFamide-like immunocytochemistry in the brain and subesophageal ganglion of Triatoma infestans (Insecta: Heteroptera). Coexpression with beta-pigment-dispersing hormone and small cardioactive peptide B. Cell Tissue Res. 2005 Aug;321(2):299-310. Epub 2005 Jun 10. PubMed PMID: 15947966. 9: Perry SJ, Dobbins AC, Schofield MG, Piper MR, Benjamin PR. Small cardioactive peptide gene: structure, expression and mass spectrometric analysis reveals a complex pattern of co-transmitters in a snail feeding neuron. Eur J Neurosci. 1999 Feb;11(2):655-62. PubMed PMID: 10051766. 10: Masinovsky B, Kempf SC, Callaway JC, Willows AO. Monoclonal antibodies to the molluscan small cardioactive peptide SCPB: immunolabeling of neurons in diverse invertebrates. J Comp Neurol. 1988 Jul 22;273(4):500-12. PubMed PMID: 3062048. 11: Gustafsson MK, Wikgren MC. Development of immunoreactivity to the invertebrate neuropeptide small cardiac peptide B in the tapeworm Diphyllobothrium dendriticum. Parasitol Res. 1989;75(5):396-400. PubMed PMID: 2657717. 12: Rothman BS, Dekruyff S, Talebian M, Menon JG, Squire CR, Yeh CH, Lee TD. Aplysia peptide neurotransmitters beta-bag cell peptide, Phe-Met-Arg-Phe-amide, and small cardioexcitatory peptide B are rapidly degraded by a leucine aminopeptidase-like activity in hemolymph. J Biol Chem. 1992 Dec 15;267(35):25135-40. PubMed PMID: 1460014. 13: Pieroni JP, Byrne JH. Differential effects of serotonin, FMRFamide, and small cardioactive peptide on multiple, distributed processes modulating sensorimotor synaptic transmission in Aplysia. J Neurosci. 1992 Jul;12(7):2633-47. PubMed PMID: 1319479. 14: Friedman AK, Weiss KR, Cropper EC. Specificity of repetition priming: the role of chemical coding. J Neurosci. 2015 Apr 22;35(16):6326-34. doi: 10.1523/JNEUROSCI.4562-14.2015. PubMed PMID: 25904786; PubMed Central PMCID: PMC4405554. 15: Santama N, Brierley M, Burke JF, Benjamin PR. Neural network controlling feeding in Lymnaea stagnalis: immunocytochemical localization of myomodulin, small cardioactive peptide, buccalin, and FMRFamide-related peptides. J Comp Neurol. 1994 Apr 15;342(3):352-65. PubMed PMID: 7912700. 16: Fox LE, Lloyd PE. Serotonin and the small cardioactive peptides differentially modulate two motor neurons that innervate the same muscle fibers in Aplysia. J Neurosci. 1997 Aug 15;17(16):6064-74. PubMed PMID: 9236218. 17: Evans BD, Calabrese RL. Small cardioactive peptide-like immunoreactivity and its colocalization with FMRFamide-like immunoreactivity in the central nervous system of the leech Hirudo medicinalis. Cell Tissue Res. 1989 Jul;257(1):187-99. PubMed PMID: 2752408. 18: Lloyd PE, Mahon AC, Kupfermann I, Cohen JL, Scheller RH, Weiss KR. Biochemical and immunocytological localization of molluscan small cardioactive peptides in the nervous system of Aplysia californica. J Neurosci. 1985 Jul;5(7):1851-61. PubMed PMID: 3894592. 19: Billy AJ, Walters ET. Modulation of mechanosensory threshold in Aplysia by serotonin, small cardioactive peptideB (SCPB), FMRFamide, acetylcholine, and dopamine. Neurosci Lett. 1989 Oct 23;105(1-2):200-4. PubMed PMID: 2577223. 20: Cropper EC, Miller MW, Tenenbaum R, Kolks MA, Kupfermann I, Weiss KR. Structure and action of buccalin: a modulatory neuropeptide localized to an identified small cardioactive peptide-containing cholinergic motor neuron of Aplysia californica. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6177-81. PubMed PMID: 3413086; PubMed Central PMCID: PMC281928.