Synonym
ER 27319 maleate; ER-27319; ER27319; ER-27319 (maleate); ER27319Maleate
IUPAC/Chemical Name
10-(3-Aminopropyl)-3,4-dimethyl-9-acridone maleic acid
InChi Key
WVUQPGFRFBVJKH-BTJKTKAUSA-N
InChi Code
InChI=1S/C18H20N2O.C4H4O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;5-3(6)1-2-4(7)8/h3-4,6-9H,5,10-11,19H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
O=C1C2=C(C=CC=C2)N(CCCN)C3=C(C)C(C)=CC=C13.O=C(O)/C=C\C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
396.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tang S, Yu Q, Ding C. Investigational spleen tyrosine kinase (SYK) inhibitors for the treatment of autoimmune diseases. Expert Opin Investig Drugs. 2022 Feb 7. doi: 10.1080/13543784.2022.2040014. Epub ahead of print. PMID: 35130124.
2: Lusková P, Dráber P. Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr Pharm Des. 2004;10(15):1727-37. doi: 10.2174/1381612043384538. PMID: 15180535.
3: Sato Y, Teshima R, Nakamura R, Sasaki N, Morita Y, Sawada J, Kitani S. IgG- mediated signal transduction in canine mastocytoma-derived cells. Int Arch Allergy Immunol. 2002 Dec;129(4):305-13. doi: 10.1159/000067587. PMID: 12483035.
4: Andrews RP, Kepley CL, Youssef L, Wilson BS, Oliver JM. Regulation of the very late antigen-4-mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and phosphatidylinositol 3-kinase. J Leukoc Biol. 2001 Nov;70(5):776-82. PMID: 11698498.
5: Moriya K, Rivera J, Odom S, Sakuma Y, Muramato K, Yoshiuchi T, Miyamoto M, Yamada K. ER-27319, an acridone-related compound, inhibits release of antigen- induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12539-44. doi: 10.1073/pnas.94.23.12539. PMID: 9356485; PMCID: PMC25030.
