Delsoline | CAS# 509-18-2 | Hypotensive

MedKoo Cat#: 571529 | Name: Delsoline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Delsoline is a Diterpenoid alkaloid isolated from the roots of Aconitum finetianum. It has been investigated as a hypotensive and heart rate-reduction agent.

Chemical Structure

Delsoline

CAS#509-18-2

Theoretical Analysis

MedKoo Cat#: 571529

Name: Delsoline

CAS#: 509-18-2

Chemical Formula: C25H41NO7

Exact Mass: 467.2883

Molecular Weight: 467.60

Elemental Analysis: C, 64.22; H, 8.84; N, 3.00; O, 23.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Delsoline; Acomonine

IUPAC/Chemical Name

Aconitane-1,7,8-triol, 20-ethyl-4-(methoxymethyl)-6,14,16-trimethoxy-, (1-alpha,6-beta,14-alpha,16-beta)-

InChi Key

JVBLTQQBEQQLEV-FHCRINJASA-N

InChi Code

InChI=1S/C25H41NO7/c1-6-26-11-22(12-30-2)8-7-16(27)24-14-9-13-15(31-3)10-23(28,17(14)18(13)32-4)25(29,21(24)26)20(33-5)19(22)24/h13-21,27-29H,6-12H2,1-5H3/t13-,14?,15-,16-,17?,18-,19?,20-,21-,22-,23+,24-,25+/m0/s1

SMILES Code

CCN1C[C@@]2(CC[C@@H]([C@@]34C5C[C@H]6[C@@H](OC)C[C@@](C5[C@H]6OC)([C@@]([C@H](C23)OC)([C@@H]14)O)O)O)COC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 467.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang DY, Cheng MZ, Lin L, Shi Q, Hu SS, Feng MG, Cheng C. [Effects of delsoline on beating rate of cultured rat myocardial cells]. Zhongguo Yao Li Xue Bao. 1986 Nov;7(6):540-3. Chinese. PubMed PMID: 2955644. 2: Lian QS, Feng GH. [Hypotensive effect of delsoline]. Zhongguo Yao Li Xue Bao. 1985 Mar;6(1):37-40. Chinese. PubMed PMID: 3158157. 3: Meriçli F, Meriçli AH, Ulubelen A, Desai HK, Pelletier SW. Norditerpenoid and diterpenoid alkaloids from Turkish Consolida orientalis. J Nat Prod. 2001 Jun;64(6):787-9. PubMed PMID: 11421744. 4: Díaz JG, Ruiza JG, Herz W. Norditerpene and diterpene alkaloids from Aconitum variegatum. Phytochemistry. 2005 Apr;66(7):837-46. PubMed PMID: 15797610. 5: Ulubelen A, Desai HK, Hart BP, Joshi BS, Pelletier SW, Meriçli AH, Meriçli F, Ozen HC. Diterpenoid alkaloids from Consolida oliveriana. J Nat Prod. 1996 Sep;59(9):907-10. PubMed PMID: 8864243. 6: Mericl F, Mericli AH, Desai HK, Ulubelen A, Pelletier SW. Diterpenoid Alkaloids from Consolida regalis S. F.Gray subsp.paniculata (Host) Soo var. paniculata. Sci Pharm. 2017 Aug 16;69(1):61-65. doi: 10.3797/scipharm.aut-01-07. PubMed PMID: 28813032. 7: Hardick DJ, Blagbrough IS, Cooper G, Potter BV, Critchley T, Wonnacott S. Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding. J Med Chem. 1996 Nov 22;39(24):4860-6. PubMed PMID: 8941400.