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MedKoo Cat#: 527405 | Name: SD-06
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SD-06, also known as SD-06-1 and SD-0006, is a MAPK p38 alpha inhibitor for the treatment of arthritis.

Chemical Structure

SD-06
SD-06
CAS#271576-80-8

Theoretical Analysis

MedKoo Cat#: 527405

Name: SD-06

CAS#: 271576-80-8

Chemical Formula: C20H20ClN5O2

Exact Mass: 397.1306

Molecular Weight: 397.86

Elemental Analysis: C, 60.38; H, 5.07; Cl, 8.91; N, 17.60; O, 8.04

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 550.00 2 Weeks
200mg USD 950.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
271576-80-8
Synonym
SD-06; SD-06; SD-06; SD-06-1; SD06-1; SD 06-1; SD-061; SD061; SD 061;
IUPAC/Chemical Name
1-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-5-yl)piperidin-1-yl)-2-hydroxyethan-1-one
InChi Key
CATQHDWESBRRQA-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H20ClN5O2/c21-15-3-1-13(2-4-15)19-18(16-5-8-22-12-23-16)20(25-24-19)14-6-9-26(10-7-14)17(28)11-27/h1-5,8,12,14,27H,6-7,9-11H2,(H,24,25)
SMILES Code
OCC(N1CCC(C2=C(C3=NC=NC=C3)C(C4=CC=C(Cl)C=C4)=NN2)CC1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SD-06 is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α.
In vitro activity:
SD-06 has potential in the regulation of intervertebral disc degeneration. SD-06 can prevent nucleus pulposus cell degeneration by promoting cell proliferation and suppressing inflammation via the p38MAPK/HDAC4 pathway. Reference: Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):10966-10974. https://pubmed.ncbi.nlm.nih.gov/33215410/
In vivo activity:
SD-06 was effective in a rat streptococcal-cell-wall-induced arthritis model, with dramatic protective effects on paw joint integrity and bone density. In a murine collagen-induced arthritis model, equivalence was demonstrated to anti-TNFalpha treatment. SD-06 had good oral anti-inflammatory efficacy with excellent cross-species correlation between rats, cynomolgus monkeys, and humans. SD-06 suppressed expression of multiple proinflammatory proteins at both the transcriptional and translational levels. Reference: Pharmacology. 2009;84(1):42-60. https://pubmed.ncbi.nlm.nih.gov/19590255/
Solvent mg/mL mM
Solubility
DMF 10.0 25.13
DMSO 15.0 37.70
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 397.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wu YD, Guo ZG, Deng WJ, Wang JG. SD0006 promotes nucleus pulposus cell proliferation via the p38MAPK/HDAC4 pathway. Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):10966-10974. doi: 10.26355/eurrev_202011_23580. PMID: 33215410. 2. Burnette BL, Selness S, Devraj R, Jungbluth G, Kurumbail R, Stillwell L, Anderson G, Mnich S, Hirsch J, Compton R, De Ciechi P, Hope H, Hepperle M, Keith RH, Naing W, Shieh H, Portanova J, Zhang Y, Zhang J, Leimgruber RM, Monahan J. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60. doi: 10.1159/000227286. Epub 2009 Jul 4. PMID: 19590255; PMCID: PMC2790787. 3. Walker JK, Selness SR, Devraj RV, Hepperle ME, Naing W, Shieh H, Kurambail R, Yang S, Flynn DL, Benson AG, Messing DM, Dice T, Kim T, Lindmark RJ, Monahan JB, Portanova J. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8. doi: 10.1016/j.bmcl.2010.02.047. Epub 2010 Feb 14. PMID: 20227876.
In vitro protocol:
1. Wu YD, Guo ZG, Deng WJ, Wang JG. SD0006 promotes nucleus pulposus cell proliferation via the p38MAPK/HDAC4 pathway. Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):10966-10974. doi: 10.26355/eurrev_202011_23580. PMID: 33215410.
In vivo protocol:
1. Burnette BL, Selness S, Devraj R, Jungbluth G, Kurumbail R, Stillwell L, Anderson G, Mnich S, Hirsch J, Compton R, De Ciechi P, Hope H, Hepperle M, Keith RH, Naing W, Shieh H, Portanova J, Zhang Y, Zhang J, Leimgruber RM, Monahan J. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60. doi: 10.1159/000227286. Epub 2009 Jul 4. PMID: 19590255; PMCID: PMC2790787. 2. Walker JK, Selness SR, Devraj RV, Hepperle ME, Naing W, Shieh H, Kurambail R, Yang S, Flynn DL, Benson AG, Messing DM, Dice T, Kim T, Lindmark RJ, Monahan JB, Portanova J. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8. doi: 10.1016/j.bmcl.2010.02.047. Epub 2010 Feb 14. PMID: 20227876.
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