MedKoo Cat#: 562359 | Name: TC-S 7010
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-S 7010 is a selective inhibitor of Aurora kinase A.

Chemical Structure

TC-S 7010
TC-S 7010
CAS#1158838-45-9

Theoretical Analysis

MedKoo Cat#: 562359

Name: TC-S 7010

CAS#: 1158838-45-9

Chemical Formula: C31H31ClFN7O2

Exact Mass: 587.2212

Molecular Weight: 588.08

Elemental Analysis: C, 63.31; H, 5.31; Cl, 6.03; F, 3.23; N, 16.67; O, 5.44

Price and Availability

Size Price Availability Quantity
10mg USD 360.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
TC-S 7010; TC S 7010; TCS7010;
IUPAC/Chemical Name
N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
InChi Key
AKSIZPIFQAYJGF-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)
SMILES Code
O=C(NC1=CC=CC=C1Cl)C2=CC=C(NC3=NC(NC4=CC=C(CC(N5CCN(CC)CC5)=O)C=C4)=NC=C3F)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 588.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee DH, Kim CG, Lim Y, Shin SY. Aurora kinase A inhibitor TCS7010 demonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells. Oncol Lett. 2017 Dec;14(6):6571-6577. doi: 10.3892/ol.2017.7023. Epub 2017 Sep 22. PubMed PMID: 29163689; PubMed Central PMCID: PMC5686436.