GSK837149A | CAS#13616-29-0 | FAS inhibitor

MedKoo Cat#: 562335 | Name: GSK837149A

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK837149A is the first selective inhibitor of human fatty acid synthase (FAS).

Chemical Structure

GSK837149A

CAS#13616-29-0

Theoretical Analysis

MedKoo Cat#: 562335

Name: GSK837149A

CAS#: 13616-29-0

Chemical Formula: C23H22N8O5S2

Exact Mass: 554.1155

Molecular Weight: 554.60

Elemental Analysis: C, 49.81; H, 4.00; N, 20.20; O, 14.42; S, 11.56

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 Weeks
50mg	USD 1,050.00	2 Weeks

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Related CAS #

No Data

Synonym

GSK837149A; GSK-837149-A; GSK 837149 A; GSK837149; GSK 837149; GSK-837149

IUPAC/Chemical Name

N,N′-Di[4-(4-Methyl-pyrimidin-2-ylsulfamoyl)phenyl]-urea

InChi Key

RSINKZJTTORDAJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H22N8O5S2/c1-15-11-13-24-21(26-15)30-37(33,34)19-7-3-17(4-8-19)28-23(32)29-18-5-9-20(10-6-18)38(35,36)31-22-25-14-12-16(2)27-22/h3-14H,1-2H3,(H,24,26,30)(H,25,27,31)(H2,28,29,32)

SMILES Code

O=C(NC1=CC=C(S(=O)(NC2=NC=CC(C)=N2)=O)C=C1)NC3=CC=C(S(=O)(NC4=NC=CC(C)=N4)=O)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GSK837149A is the first selective inhibitor of human fatty acid synthase (FAS).

In vitro activity:

The reversible nature of the inhibition caused by GSK837149A on FAS was also demonstrated: as shown in Fig. 8, FAS could be rescued from the inhibitory effect of GSK837149A by simply removing the unbound compound by filtration and diluting to reconstitute the initial volume. Reference: FEBS J. 2008 Apr;275(7):1556-1567. https://pubmed.ncbi.nlm.nih.gov/18312417/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	5.0	9.02
	DMF:PBS (pH 7.2) (1:1)	0.5	0.90
	DMSO	5.0	9.02

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 554.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Vázquez MJ, Leavens W, Liu R, Rodríguez B, Read M, Richards S, Winegar D, Domínguez JM. Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction. FEBS J. 2008 Apr;275(7):1556-1567. doi: 10.1111/j.1742-4658.2008.06314.x. Epub 2008 Feb 25. PMID: 18312417.

In vitro protocol:

In vivo protocol:

TBD

1: Vázquez MJ, Leavens W, Liu R, Rodríguez B, Read M, Richards S, Winegar D, Domínguez JM. Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction. FEBS J. 2008 Apr;275(7):1556-67. doi: 10.1111/j.1742-4658.2008.06314.x. Epub 2008 Feb 25. PubMed PMID: 18312417.