Synonym
Phenylbutazone calcium; DA-241; DA241; DA 241; P 241; Phenylbutazone calcium salt;
IUPAC/Chemical Name
calcium 4-butyl-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrazol-3-olate
InChi Key
XMVFRSAMWBGRNR-UHFFFAOYSA-L
InChi Code
InChI=1S/2C19H20N2O2.Ca/c2*1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16;/h2*4-13,22H,2-3,14H2,1H3;/q;;+2/p-2
SMILES Code
[O-]C1=C(CCCC)C(N(C2=CC=CC=C2)N1C3=CC=CC=C3)=O.[O-]C4=C(CCCC)C(N(C5=CC=CC=C5)N4C6=CC=CC=C6)=O.[Ca+2]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
654.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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8: SPILDBORGHS G, NEBO F. [Evaluation of the use of the calcium salt of phenylbutazone in rheumatoid arthritis in adults]. Rev Bras Med. 1957 Dec;14(12):859-61. Portuguese. PubMed PMID: 13568199.
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17: Spahn H, Mutschler E, Geissler HE, Faust-Tinnefeldt G. [Comparison of bumadizone-, phenylbutazone- and oxyphenbutazone-plasma levels after a single oral dose of phenylbutazone and of bumadizone, respectively (author's transl)]. Arzneimittelforschung. 1981;31(3):499-503. German. PubMed PMID: 6894380.
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19: Neuschl J, Kohút A, Nicák A. [The relationship between the levels of calcium on the stomach wall and in the blood and ulcerogenic effect of phenylbutazone and reserpine in intact, adrenalectomized and vagotomized rats of various age (author's transl)]. Cesk Gastroenterol Vyz. 1978 Mar;32(2):85-90. Slovak. PubMed PMID: 657308.
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