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MedKoo Cat#: 581138 | Name: DA 1131

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DA 1131 is a new carbapenem antibiotic, undergoes renal metabolism by renal dehydropeptidase I (DHP-I), located on the brush border of the proximal tubular cell. Species differences with the effects of cilastatin, a renal DHP-I inhibitor, after a 1-min intravenous infusion of DA-1131, with or without cilastatin, to rats, rabbits, and dogs.

Chemical Structure

DA 1131
DA 1131
CAS#169285-98-7

Theoretical Analysis

MedKoo Cat#: 581138

Name: DA 1131

CAS#: 169285-98-7

Chemical Formula: C18H27N3O6S2

Exact Mass: 445.1341

Molecular Weight: 445.55

Elemental Analysis: C, 48.52; H, 6.11; N, 9.43; O, 21.55; S, 14.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DA 1131; DA-1131; DA1131;
IUPAC/Chemical Name
(4R,5S)-6-(1-hydroxyethyl)-4-methyl-3-(((3S,5S)-5-((E)-3-(methylsulfonamido)prop-1-en-1-yl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
InChi Key
UXCCOLVNQUBDAJ-FGQVXFQSSA-N
InChi Code
InChI=1S/C18H27N3O6S2/c1-9-14-13(10(2)22)17(23)21(14)15(18(24)25)16(9)28-12-7-11(19-8-12)5-4-6-20-29(3,26)27/h4-5,9-14,19-20,22H,6-8H2,1-3H3,(H,24,25)/b5-4+/t9-,10?,11-,12+,13?,14-/m1/s1
SMILES Code
C[C@@H]1[C@@H]2C(C(=O)N2C(=C1S[C@H]3C[C@H](NC3)/C=C/CNS(=O)(=O)C)C(=O)O)C(C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 445.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim SH, Kim WB, Lee MG. Effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in rats and rabbits. Antimicrob Agents Chemother. 1999 Jan;43(1):96-9. PubMed PMID: 9869572; PubMed Central PMCID: PMC89027. 2: Kim SH, Shim HJ, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure. Antimicrob Agents Chemother. 1998 May;42(5):1217-21. PubMed PMID: 9593153; PubMed Central PMCID: PMC105781. 3: Kim SH, Kwon JW, Lee MG. Pharmacokinetics and tissue distribution of a new carbapenem DA-1131, after intravenous administration to mice, rats, rabbits and dogs. Biopharm Drug Dispos. 1998 May;19(4):219-29. PubMed PMID: 9604121. 4: Kim SH, Kwon JW, Kim WB, Lee MG. Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. Antimicrob Agents Chemother. 1999 Oct;43(10):2524-7. PubMed PMID: 10508037; PubMed Central PMCID: PMC89513. 5: Kim SH, Kim WB, Lee MG. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with alloxan-induced diabetes mellitus. Biopharm Drug Dispos. 1998 Jul;19(5):303-8. PubMed PMID: 9673782. 6: Park SW, We JS, Kim GW, Choi SH, Park HS. Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). Antimicrob Agents Chemother. 2002 Feb;46(2):575-7. PubMed PMID: 11796382; PubMed Central PMCID: PMC127065. 7: Kim SH, Kim WB, Kwon JW, Lee MG. Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits. Biopharm Drug Dispos. 1999 Apr;20(3):125-9. PubMed PMID: 10211864. 8: Kim SH, Kim WB, Lee MG. No effect of probenecid on the renal excretion mechanism of a new carbapenem, DA-1131, in dogs. Res Commun Mol Pathol Pharmacol. 1998 Jul;101(1):85-92. PubMed PMID: 9755846. 9: Kim SH, Kwon JW, Kim WB, Lee I, Lee MG. Effects of water deprivation for 72 hours on the pharmacokinetics of a new carbapenem, DA-1131, in rats. Life Sci. 2002 Sep 27;71(19):2291-8. PubMed PMID: 12215376. 10: Kim SH, Kim WB, Lee MG. Interspecies pharmacokinetic scaling of a new carbapenem, DA-1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics. Biopharm Drug Dispos. 1998 May;19(4):231-5. PubMed PMID: 9604122. 11: Kim SH, Kim WB, Lee MG. Pharmacokinetic changes of a new carbapenem, DA-1131, after intravenous administration to spontaneously hypertensive rats and deoxycorticosterone acetate-salt-induced hypertensive rats. Drug Metab Dispos. 1999 Jun;27(6):710-6. PubMed PMID: 10348801. 12: Lee ED, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Determination of a new carbapenem antibiotic, DA-1131, in rat plasma, urine, and bile by column-switching high-performance liquid chromatography. Res Commun Mol Pathol Pharmacol. 1996 Nov;94(2):171-80. PubMed PMID: 8987114. 13: Kim SH, Kim WB, Lee MG. Stability, tissue metabolism, tissue distribution, and blood partition of DA-1131, a new carbapenem. Res Commun Mol Pathol Pharmacol. 1995 Dec;90(3):347-62. PubMed PMID: 8746482. 14: Kim SH, Kwon JW, Yang J, Lee MG. Determination of a new carbapenem derivative, DA-1131, in plasma and urine by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Jan 10;688(1):95-9. PubMed PMID: 9029318.

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