MedKoo Cat#: 128371 | Name: THP1 Lipid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

THP1 lipid is an ionizable cationic lipid (pKa = 5.451) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.

Chemical Structure

THP1 Lipid
THP1 Lipid
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128371

Name: THP1 Lipid

CAS#: N/A

Chemical Formula: C26H48N2O4

Exact Mass: 452.3614

Molecular Weight: 452.68

Elemental Analysis: C, 68.99; H, 10.69; N, 6.19; O, 14.14

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 750.00 2 Weeks
25mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
THP1 Lipid; THP-1 Lipid; THP 1 Lipid; Tetrahydropyrimidine 1 Lipid
IUPAC/Chemical Name
diethyl 1,3-dioctyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate
InChi Key
BOOXYBQPTLWJAA-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H48N2O4/c1-5-9-11-13-15-17-19-27-21-23(25(29)31-7-3)24(26(30)32-8-4)28(22-27)20-18-16-14-12-10-6-2/h5-22H2,1-4H3
SMILES Code
O=C(OCC)C1=C(C(OCC)=O)N(CCCCCCCC)CN(CCCCCCCC)C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 452.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL