LG190119 | CAS#233268-77-4

MedKoo Cat#: 407887 | Name: LG190119

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG190119 is a nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium. LG190119 effectively inhibited LNCaP xenograft tumor growth without increased serum calcium levels or any other apparent side effects. Compounds of this class may represent promising new therapeutics for treatment of prostate cancer and other cancers with fewer undesirable side effects than currently used drugs.

Chemical Structure

LG190119

CAS#233268-77-4

Theoretical Analysis

MedKoo Cat#: 407887

Name: LG190119

CAS#: 233268-77-4

Chemical Formula: C32H44O4

Exact Mass: 492.3240

Molecular Weight: 492.70

Elemental Analysis: C, 78.01; H, 9.00; O, 12.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LG190119; LG-190119; LG 190119.

IUPAC/Chemical Name

1,1'-[Cyclohexylidenebis[(2-methyl-4,1-phenylene)oxy]]bis[3,3-dimethyl-2-butanone]

InChi Key

LHIDEEADXIZBIN-UHFFFAOYSA-N

InChi Code

InChI=1S/C32H44O4/c1-22-18-24(12-14-26(22)35-20-28(33)30(3,4)5)32(16-10-9-11-17-32)25-13-15-27(23(2)19-25)36-21-29(34)31(6,7)8/h12-15,18-19H,9-11,16-17,20-21H2,1-8H3

SMILES Code

CC1=CC(C2(C3=CC=C(OCC(C(C)(C)C)=O)C(C)=C3)CCCCC2)=CC=C1OCC(C(C)(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

LG190119 is a nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium.

In vitro activity:

TBD

In vivo activity:

In the established tumor study, LG190119 at each dose resulted in significant tumor growth inhibition without hypercalcemia at both 10 and 15 days. LG190119 effectively inhibited LNCaP xenograft tumor growth without increased serum calcium levels or any other apparent side effects. Reference: Prostate. 2001 Nov 1;49(3):224-33. https://pubmed.ncbi.nlm.nih.gov/11746268/

Preparing Stock Solutions

The following data is based on the product molecular weight 492.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Polek TC, Murthy S, Blutt SE, Boehm MF, Zou A, Weigel NL, Allegretto EA. Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium. Prostate. 2001 Nov 1;49(3):224-33. doi: 10.1002/pros.1138. PMID: 11746268.

In vitro protocol:

TBD

In vivo protocol:

1: Polek TC, Murthy S, Blutt SE, Boehm MF, Zou A, Weigel NL, Allegretto EA. Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium. Prostate. 2001 Nov 1;49(3):224-33. PubMed PMID: 11746268.