MedKoo Cat#: 206949 | Name: Deltazinone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deltazinone is highly potent and selective PDEδ inhibitor. Deltazinone exhibits less unspecific cytotoxicity than the previously reported Deltarasin and demonstrates a high correlation with the phenotypic effect of PDEδ knockdown in a set of human pancreatic cancer cell lines.

Chemical Structure

Deltazinone
Deltazinone
CAS#894554-89-3

Theoretical Analysis

MedKoo Cat#: 206949

Name: Deltazinone

CAS#: 894554-89-3

Chemical Formula: C27H31N5O2

Exact Mass: 457.2478

Molecular Weight: 457.58

Elemental Analysis: C, 70.87; H, 6.83; N, 15.31; O, 6.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Deltazinone
IUPAC/Chemical Name
4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)-N-(2-phenylpropyl)butanamide
InChi Key
HZNKNJCWLQLQMJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H31N5O2/c1-18-12-14-23(15-13-18)32-21(4)25-20(3)29-31(27(34)26(25)30-32)16-8-11-24(33)28-17-19(2)22-9-6-5-7-10-22/h5-7,9-10,12-15,19H,8,11,16-17H2,1-4H3,(H,28,33)
SMILES Code
O=C(NCC(C1=CC=CC=C1)C)CCCN2N=C(C)C3=C(C)N(C4=CC=C(C)C=C4)N=C3C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of prenylated Ras.

Preparing Stock Solutions

The following data is based on the product molecular weight 457.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI. Identification of pyrazolopyridazinones as PDEδ inhibitors. Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360. PubMed PMID: 27094677; PubMed Central PMCID: PMC4843002.