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MedKoo Cat#: 122946 | Name: COH-SR4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

COH-SR4 is a Mitochondrial Uncoupler

Chemical Structure

COH-SR4
CAS#73439-19-7

Theoretical Analysis

MedKoo Cat#: 122946

Name: COH-SR4

CAS#: 73439-19-7

Chemical Formula: C13H8Cl4N2O

Exact Mass: 347.9400

Molecular Weight: 350.02

Elemental Analysis: C, 44.61; H, 2.30; Cl, 40.51; N, 8.00; O, 4.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
COH-SR4; COHSR4; COH SR4
IUPAC/Chemical Name
1,3-bis(3,5-dichlorophenyl)urea
InChi Key
VKVJIWVUYNTBEZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H8Cl4N2O/c14-7-1-8(15)4-11(3-7)18-13(20)19-12-5-9(16)2-10(17)6-12/h1-6H,(H2,18,19,20)
SMILES Code
O=C(NC1=CC(Cl)=CC(Cl)=C1)NC2=CC(Cl)=CC(Cl)=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 350.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Figarola JL, Rahbar S. Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. Int J Mol Med. 2013 May;31(5):1166-76. doi: 10.3892/ijmm.2013.1313. Epub 2013 Mar 21. PMID: 23525347. 2: Figarola JL, Singhal P, Rahbar S, Gugiu BG, Awasthi S, Singhal SS. COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. PLoS One. 2013 Dec 20;8(12):e83801. doi: 10.1371/journal.pone.0083801. PMID: 24376752; PMCID: PMC3869817. 3: Singhal SS, Figarola J, Singhal J, Leake K, Nagaprashantha L, Lincoln C, Gabriel Gugiu B, Horne D, Jove R, Awasthi S, Rahbar S. 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27. doi: 10.1016/j.bcp.2012.08.020. Epub 2012 Aug 28. PMID: 22959823; PMCID: PMC3747778. 4: Singhal SS, Figarola J, Singhal J, Nagaprashantha L, Berz D, Rahbar S, Awasthi S. Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72. doi: 10.1016/j.bcp.2013.09.022. Epub 2013 Oct 4. PMID: 24099794; PMCID: PMC4186798. 5: Limbach KE, Wen W, Xing Q, Yan J, Yim JH. Baicalein activates 5' adenosine monophosphate-activated protein kinase, inhibits the mammalian target of rapamycin, and exhibits antiproliferative effects in pancreatic neuroendocrine tumors in vitro and in vivo. Surgery. 2023 Jan;173(1):12-18. doi: 10.1016/j.surg.2022.07.030. Epub 2022 Oct 4. PMID: 36207198.