Synonym
D 2343; D2343; D-2343
IUPAC/Chemical Name
Benzenemethanol, 4-hydroxy-alpha-(((3-(2-methoxyphenyl)-1,1-dimethylpropyl)amino)methyl)-
InChi Key
QQNHGKXYJUREIZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H27NO3/c1-20(2,13-12-16-6-4-5-7-19(16)24-3)21-14-18(23)15-8-10-17(22)11-9-15/h4-11,18,21-23H,12-14H2,1-3H3
SMILES Code
OC(CNC(C)(C)CCC1=CC=CC=C1OC)C2=CC=C(O)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
329.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Löfdahl CG, Bengtsson B, Svedmyr K, Svedmyr N. Two new beta 2-adrenoceptor agonists, D-2343 and QH 25, studied in asthmatic patients. Allergy. 1982 Jul;37(5):351-7. PubMed PMID: 6127039.
2: Löfdahl CG, Svedmyr N. Selectivity of beta-adrenergic stimulating and blocking agents. Eur J Respir Dis Suppl. 1984;136:101-13. PubMed PMID: 6145618.
3: Löfdahl CG, Svedmyr K, Svedmyr N, Andersson P, Bengtsson B, Olsson OA, Waldeck B. Comparison of beta 2-adrenoceptor stimulation in bronchial and skeletal muscle in experimental and clinical studies. Eur J Respir Dis Suppl. 1984;135:124-7. PubMed PMID: 6329798.
4: Olsson OA, Gustafsson B. The effect of D2343 in transmurally stimulated rabbit isthmus muscle. Acta Pharmacol Toxicol (Copenh). 1985 May;56(5):427-30. PubMed PMID: 2863921.
5: Löfdahl CG, Svedmyr N. A new beta 2-adrenoceptor agonist--D 2343--with long duration. Inhalation comparison with terbutaline in asthmatics. Allergy. 1984 Aug;39(6):485-9. PubMed PMID: 6437263.
6: Olsson OA, Ahlquist B, Gustafsson B. A new beta 2-adrenoceptor agonist with alpha 1-adrenoceptor blocking properties. Acta Pharmacol Toxicol (Copenh). 1981 Apr;48(4):340-8. PubMed PMID: 6121453.
7: Ingemarsson I, Arulkumaran S, Chua S. Effects of D2343, a new beta-mimetic drug, and terbutaline on spontaneous term labor. Gynecol Obstet Invest. 1988;26(2):130-5. PubMed PMID: 3146531.
8: Olsson OA, Ahlquist B, Gustafsson B, Persson G. The effects in myometrial preparations of D2343, a beta 2-adrenoceptor agonist possessing alpha 1-receptor blocking qualities. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):391-7. PubMed PMID: 6152105.
