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MedKoo Cat#: 406166 | Name: OM-137
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

OM137 is an inhibitor of Aurora kinases. which is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel.

Chemical Structure

OM-137
OM-137
CAS#292170-13-9

Theoretical Analysis

MedKoo Cat#: 406166

Name: OM-137

CAS#: 292170-13-9

Chemical Formula: C13H14N4O3S

Exact Mass: 306.0787

Molecular Weight: 306.34

Elemental Analysis: C, 50.97; H, 4.61; N, 18.29; O, 15.67; S, 10.47

Price and Availability

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5mg USD 220.00
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Related CAS #
No Data
Synonym
OM-137; OM137; OM 137
IUPAC/Chemical Name
(E)-2-amino-N'-(4-hydroxy-3-methoxybenzylidene)-4-methylthiazole-5-carbohydrazide
InChi Key
AMHQGUWEVRTTJB-GIDUJCDVSA-N
InChi Code
InChI=1S/C13H14N4O3S/c1-7-11(21-13(14)16-7)12(19)17-15-6-8-3-4-9(18)10(5-8)20-2/h3-6,18H,1-2H3,(H2,14,16)(H,17,19)/b15-6+
SMILES Code
O=C(C1=C(C)N=C(N)S1)N/N=C/C2=CC=C(O)C(OC)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
        
Product Data
Product Data
Instruction
View handling instruction
Biological target:
OM137 is an inhibitor of Aurora kinases.
In vitro activity:
This study characterizes one of the compounds, OM137, as an inhibitor of Aurora kinases. This study finds that this compound is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel. Reference: Cancer Res. 2009 Feb 15;69(4):1509-16. https://pubmed.ncbi.nlm.nih.gov/19190331/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 306.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ. A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3. PMID: 19190331; PMCID: PMC2655231.
In vitro protocol:
DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ. A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3. PMID: 19190331; PMCID: PMC2655231.
In vivo protocol:
TBD
 1: DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ. A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3. PubMed PMID: 19190331; PubMed Central PMCID: PMC265523.

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