WB-308 | CAS#1373764-87-4 | EGFR inhibitor

MedKoo Cat#: 562273 | Name: WB-308

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WB-308 is a inhibitor of the epidermal growth factor receptor (EGFR). It acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis.

Chemical Structure

WB-308

CAS#1373764-87-4

Theoretical Analysis

MedKoo Cat#: 562273

Name: WB-308

CAS#: 1373764-87-4

Chemical Formula: C19H17FN2O

Exact Mass: 308.1325

Molecular Weight: 308.35

Elemental Analysis: C, 74.01; H, 5.56; F, 6.16; N, 9.08; O, 5.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

WB-308; WB 308; WB308;

IUPAC/Chemical Name

1-(6-Fluoro-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2-phenyl-ethanone

InChi Key

HLKIUOZYYGXOOR-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H17FN2O/c20-14-6-7-17-16(11-14)15-8-9-22(12-18(15)21-17)19(23)10-13-4-2-1-3-5-13/h1-7,11,21H,8-10,12H2

SMILES Code

FC1=CC2=C(NC3=C2CCN(C(CC4=CC=CC=C4)=O)C3)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 308.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li J, Deng H, Hu M, Fang Y, Vaughn A, Cai X, Xu L, Wan W, Li Z, Chen S, Yang X, Wu S, Xiao J. Inhibition of non-small cell lung cancer (NSCLC) growth by a novel small molecular inhibitor of EGFR. Oncotarget. 2015 Mar 30;6(9):6749-61. PubMed PMID: 25730907; PubMed Central PMCID: PMC4466647.