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MedKoo Cat#: 562239 | Name: PDE7 inhibitor S14

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor. It acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element binding protein (CREB) pathway, exerting neuroprotection in an Alzheimer's disease (AD) model.

Chemical Structure

PDE7 inhibitor S14
PDE7 inhibitor S14
CAS#18741-24-7

Theoretical Analysis

MedKoo Cat#: 562239

Name: PDE7 inhibitor S14

CAS#: 18741-24-7

Chemical Formula: C14H10N2OS

Exact Mass: 254.0514

Molecular Weight: 254.30

Elemental Analysis: C, 66.12; H, 3.96; N, 11.02; O, 6.29; S, 12.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
PDE7 inhibitor S14; PDE7 inhibitor-S14; S14;
IUPAC/Chemical Name
3-Phenyl-2-sulfanylquinazolin-4(3H)-one
InChi Key
CRGOYNYLYMPGKH-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10N2OS/c17-13-11-8-4-5-9-12(11)15-14(18)16(13)10-6-2-1-3-7-10/h1-9H,(H,15,18)
SMILES Code
O=C1N(C2=CC=CC=C2)C(S)=NC3=C1C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 254.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bartolome F, de la Cueva M, Pascual C, Antequera D, Fernandez T, Gil C, Martinez A, Carro E. Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimers Res Ther. 2018 Feb 20;10(1):24. doi: 10.1186/s13195-018-0352-4. PubMed PMID: 29458418; PubMed Central PMCID: PMC5819290. 2: Morales-Garcia JA, Echeverry-Alzate V, Alonso-Gil S, Sanz-SanCristobal M, Lopez-Moreno JA, Gil C, Martinez A, Santos A, Perez-Castillo A. Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo. Stem Cells. 2017 Feb;35(2):458-472. doi: 10.1002/stem.2480. Epub 2016 Sep 16. PubMed PMID: 27538853. 3: Morales-Garcia JA, Alonso-Gil S, Gil C, Martinez A, Santos A, Perez-Castillo A. Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats. Stem Cells Transl Med. 2015 Jun;4(6):564-75. doi: 10.5966/sctm.2014-0277. Epub 2015 Apr 29. PubMed PMID: 25925836; PubMed Central PMCID: PMC4449102. 4: Perez-Gonzalez R, Pascual C, Antequera D, Bolos M, Redondo M, Perez DI, Pérez-Grijalba V, Krzyzanowska A, Sarasa M, Gil C, Ferrer I, Martinez A, Carro E. Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease. Neurobiol Aging. 2013 Sep;34(9):2133-45. doi: 10.1016/j.neurobiolaging.2013.03.011. Epub 2013 Apr 9. PubMed PMID: 23582662.