Synonym
Carmethizole hydrochloride; CCRIS9390; CCRIS-9390 CCRIS 9390
IUPAC/Chemical Name
1H-Imidazole-4,5-dimethanol, 1-methyl-2-(methylthio)-, bis(methylcarbamate) (ester)monohydrochloride
InChi Key
ZUIGQZNTMIGKHP-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H18N4O4S.ClH/c1-12-10(16)18-5-7-8(6-19-11(17)13-2)15(3)9(14-7)20-4;/h5-6H2,1-4H3,(H,12,16)(H,13,17);1H
SMILES Code
CSC1=NC(COC(NC)=O)=C(COC(NC)=O)N1C.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
338.81
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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6: Anderson WK, Bhattacharjee D, Houston DM. Design, synthesis, antineoplastic activity, and chemical properties of bis(carbamate) derivatives of 4,5-bis(hydroxymethyl)imidazole. J Med Chem. 1989 Jan;32(1):119-27. doi: 10.1021/jm00121a023. PMID: 2909723.
7: Beijnen JH, Flora KP, Halbert GW, Henrar RE, Slack JA. CRC/EORTC/NCI Joint Formulation Working Party: experiences in the formulation of investigational cytotoxic drugs. Br J Cancer. 1995 Jul;72(1):210-8. doi: 10.1038/bjc.1995.305. PMID: 7599054; PMCID: PMC2034157.
8: Waud WR, Harrison SD Jr, Gilbert KS, Laster WR Jr, Griswold DP Jr. Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia. Cancer Chemother Pharmacol. 1991;27(6):456-63. doi: 10.1007/BF00685160. PMID: 1849465.
